000			02924nam a22004695i 4500
001			u372604
003			SIRSI
005			20160812084106.0
007			cr nn 008mamaa
008			100528s2010 xxu| s |||| 0|eng d
020			_a9781607615545 _9978-1-60761-554-5
040			_cMX-MeUAM
050		4	_aRC254-282
082	0	4	_a616.994 _223
100	1		_aRoodman, G. David. _eeditor.
245	1	0	_aMyeloma Bone Disease _h[recurso electrónico] / _cedited by G. David Roodman.
264		1	_aTotowa, NJ : _bHumana Press, _c2010.
300			_aX, 252p. 75 illus., 43 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Clinical Oncology
505	0		_aClinical Presentation of Myeloma Bone Disease -- Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias -- Biochemical Markers of Bone Remodeling in Multiple Myeloma -- Radiation Therapy in Multiple Myeloma -- Surgical Management of Bone Disease -- Bisphosphonates in the Treatment of Myeloma Bone Disease -- Osteonecrosis of the Jaw -- Murine Models of Myeloma Bone Disease: The Importance of Choice -- RANK Ligand Is a Therapeutic Target in Multiple Myeloma -- Osteoclast Activation in Multiple Myeloma -- Potential Role of IMiDs and Other Agents as Therapy for Myeloma Bone Disease -- Proteasome Inhibitors and the Wnt Signaling Pathway in Myeloma Bone Disease -- Mechanisms Involved in Osteoblast Suppression in Multiple Myeloma.
520			_aThis state-of-the-art book presents the forefront in the science and clinical management of myeloma bone disease. Assembling the work of the world's premier thought leaders, this book begins with sections on clinical presentation, imaging, and biochemical markers and then goes on to discuss radiation, surgical, and medical therapies. Specific chapters are devoted to bisphosphonates and novel therapeutic agents, such as RANKL inhibitors, Wnt signaling inhibitors, and IMiDs. The mechanisms of osteoclast activation and osteoblast suppression in multiple myeloma are also explored. Myeloma Bone Disease is a valuable resource for medical, surgical, and radiation oncologists and cancer researchers.
650		0	_aMedicine.
650		0	_aRadiotherapy.
650		0	_aHematology.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aHematology.
650	2	4	_aRadiotherapy.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781607615538
830		0	_aCurrent Clinical Oncology
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-60761-554-5
596			_a19
942			_cLIBRO_ELEC
999			_c200484 _d200484