000 | 03253nam a22004935i 4500 | ||
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001 | u372729 | ||
003 | SIRSI | ||
005 | 20160812084112.0 | ||
007 | cr nn 008mamaa | ||
008 | 110331s2011 xxk| s |||| 0|eng d | ||
020 |
_a9781848826441 _9978-1-84882-644-1 |
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040 | _cMX-MeUAM | ||
050 | 4 | _aRB155-155.8 | |
050 | 4 | _aQH431 | |
082 | 0 | 4 |
_a611.01816 _223 |
082 | 0 | 4 |
_a599.935 _223 |
100 | 1 |
_aRoach, Helmtrud I. _eeditor. |
|
245 | 1 | 0 |
_aEpigenetic Aspects of Chronic Diseases _h[recurso electrónico] / _cedited by Helmtrud I. Roach, Felix Bronner, Richard O.C. Oreffo. |
264 | 1 |
_aLondon : _bSpringer London : _bImprint: Springer, _c2011. |
|
300 |
_aXVII, 236 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aEpigenetics and Chronic Diseases: An Overview -- Techniques to Study DNA Methylation and Histone Modification -- Mechanisms of Epigenetic Gene Silencing -- Mechanisms of Epigenetic Gene Activation in Disease: Dynamics of DNA Methylation and Demethylation -- The Role of Histone Demethylases in Disease -- Autoimmune Diseases -- Epigenetics of Rheumatoid Arthritis -- DNA Methylation Changes in Osteoarthritis -- Epigenetics and Type 2 Diabetes -- Epigenetic Regulation of Asthma and Allergic Diseases -- Epigenetics in Psychiatry -- Epigenetics and Late-Onset Alzheimer’s Disease -- Epigenetic Mechanisms in the Developmental Origins of Adult Disease -- Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease -- Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic Syndrome. | |
520 | _aEpigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aInternal medicine. | |
650 | 0 | _aBiochemistry. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aMedical Biochemistry. |
650 | 2 | 4 | _aInternal Medicine. |
700 | 1 |
_aBronner, Felix. _eeditor. |
|
700 | 1 |
_aOreffo, Richard O.C. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781848826434 |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-84882-644-1 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c200609 _d200609 |