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001 | u373004 | ||
003 | SIRSI | ||
005 | 20160812084125.0 | ||
007 | cr nn 008mamaa | ||
008 | 100825s2010 sz | s |||| 0|eng d | ||
020 |
_a9783034602280 _9978-3-0346-0228-0 |
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040 | _cMX-MeUAM | ||
050 | 4 | _aQP351-495 | |
082 | 0 | 4 |
_a573.8 _223 |
100 | 1 |
_aHökfelt, Tomas. _eeditor. |
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245 | 1 | 0 |
_aGalanin _h[recurso electrónico] / _cedited by Tomas Hökfelt. |
264 | 1 |
_aBasel : _bSpringer Basel : _bImprint: Springer, _c2010. |
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300 |
_aX, 286 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aExperientia Supplementum, _x1023-294X ; _v102 |
|
505 | 0 | _aGalanin: A Multitalented Neuropeptide -- Galanin, Galanin Receptors, and Drug Targets -- Galanin Acts as a Trophic Factor to the Central and Peripheral Nervous Systems -- Galanin and Spinal Pain Mechanisms: Past, Present, and Future -- Galanin Family of Peptides in Skin Function -- Galanin in Glia: Expression and Potential Roles in the CNS -- Galanin and the Neuroendocrine Axes -- Galanin and Consummatory Behavior: Special Relationship with Dietary Fat, Alcohol and Circulating Lipids -- Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galanin -- Galanin Impairs Cognitive Abilities in Rodents: Relevance to Alzheimer’s Disease -- Neuroprotective Role for Galanin in Alzheimer’s Disease -- Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour -- Galanin and Epilepsy -- Galanin and Addiction -- Galanin Systems and Ischemia: Peptide and Receptor Plasticity in Neurons and Oligodendroglial Precursors -- The Galanin System in Cancer -- Galanin Systems in Non-mammalian Vertebrates with Special Focus on Fishes -- Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproduction. | |
520 | _aGalanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions. | ||
650 | 0 | _aLife sciences. | |
650 | 0 | _aNeurobiology. | |
650 | 1 | 4 | _aLife Sciences. |
650 | 2 | 4 | _aNeurobiology. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783034602273 |
830 | 0 |
_aExperientia Supplementum, _x1023-294X ; _v102 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-0346-0228-0 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
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_c200884 _d200884 |