| 000 | 02651nam a22004095i 4500 | ||
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| 001 | u373303 | ||
| 003 | SIRSI | ||
| 005 | 20160812084139.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 101224s2011 gw | s |||| 0|eng d | ||
| 020 |
_a9783540898917 _9978-3-540-89891-7 |
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| 040 | _cMX-MeUAM | ||
| 050 | 4 | _aRM1-950 | |
| 082 | 0 | 4 |
_a615 _223 |
| 100 | 1 |
_aVogel, Hans Gerhard. _eeditor. |
|
| 245 | 1 | 0 |
_aDrug Discovery and Evaluation: Methods in Clinical Pharmacology _h[recurso electrónico] / _cedited by Hans Gerhard Vogel, Jochen Maas, Alexander Gebauer. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011. |
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| 300 |
_aXII, 564p. 138 illus.. eReference. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 520 | _aDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology". | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aToxicology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 700 | 1 |
_aMaas, Jochen. _eeditor. |
|
| 700 | 1 |
_aGebauer, Alexander. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783540898900 |
| 856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-540-89891-7 |
| 596 | _a19 | ||
| 942 | _cLIBRO_ELEC | ||
| 999 |
_c201183 _d201183 |
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