000			02779nam a22004575i 4500
001			u373372
003			SIRSI
005			20160812084143.0
007			cr nn 008mamaa
008			100301s2010 gw | s |||| 0|eng d
020			_a9783642012228 _9978-3-642-01222-8
040			_cMX-MeUAM
050		4	_aRC254-282
082	0	4	_a616.994 _223
100	1		_aMartens, Uwe M. _eeditor.
245	1	0	_aSmall Molecules in Oncology _h[recurso electrónico] / _cedited by Uwe M. Martens.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2010.
300			_aXVI, 238 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aRecent Results in Cancer Research, _x0080-0015 ; _v184
505	0		_aProtein kinase inhibitors -- Imatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor -- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy -- GDC-0449 - Targeting the Hedgehog Signaling Pathway.
520			_aExtensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHematology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aHematology.
650	2	4	_aCancer Research.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642012211
830		0	_aRecent Results in Cancer Research, _x0080-0015 ; _v184
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-01222-8
596			_a19
942			_cLIBRO_ELEC
999			_c201252 _d201252