000 | 02779nam a22004575i 4500 | ||
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001 | u373372 | ||
003 | SIRSI | ||
005 | 20160812084143.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2010 gw | s |||| 0|eng d | ||
020 |
_a9783642012228 _9978-3-642-01222-8 |
||
040 | _cMX-MeUAM | ||
050 | 4 | _aRC254-282 | |
082 | 0 | 4 |
_a616.994 _223 |
100 | 1 |
_aMartens, Uwe M. _eeditor. |
|
245 | 1 | 0 |
_aSmall Molecules in Oncology _h[recurso electrónico] / _cedited by Uwe M. Martens. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2010. |
|
300 |
_aXVI, 238 p. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aRecent Results in Cancer Research, _x0080-0015 ; _v184 |
|
505 | 0 | _aProtein kinase inhibitors -- Imatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor -- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy -- GDC-0449 - Targeting the Hedgehog Signaling Pathway. | |
520 | _aExtensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 0 | _aHematology. | |
650 | 1 | 4 | _aMedicine & Public Health. |
650 | 2 | 4 | _aOncology. |
650 | 2 | 4 | _aHematology. |
650 | 2 | 4 | _aCancer Research. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642012211 |
830 | 0 |
_aRecent Results in Cancer Research, _x0080-0015 ; _v184 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-01222-8 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c201252 _d201252 |