000			03327nam a22005175i 4500
001			u373957
003			SIRSI
005			20160812084211.0
007			cr nn 008mamaa
008			101125s2011 gw | s |||| 0|eng d
020			_a9783642111839 _9978-3-642-11183-9
040			_cMX-MeUAM
050		4	_aRJ1-570
082	0	4	_a618.92 _223
100	1		_aLaron, Zvi. _eeditor.
245	1	0	_aLaron Syndrome - From Man to Mouse _h[recurso electrónico] : _bLessons from Clinical and Experimental Experience / _cedited by Zvi Laron, J. Kopchick.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2011.
300			_aXIV, 531p. 447 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aFrom the Content: Part I - Laron Syndrome in Man -- Clinical Aspects -- History of the Israeli Cohort of Laron Syndrome Patients -- Early Investigations -- Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome -- Diagnosis of Laron Syndrome -- Genetic Aspects -- Clinical Evaluation -- Perinatal Evaluation -- Perinatal Development ;Laron Syndrome -- Linear Growth Pattern of Untreated Laron Syndrome Patients -- Head Shape, Size and Growth of Untreated Patients with Laron Syndrome -- Sexual Development in Patients with Laron Syndrome.
520			_aLaron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aHuman physiology.
650		0	_aInternal medicine.
650		0	_aEndocrinology.
650		0	_aPediatrics.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPediatrics.
650	2	4	_aEndocrinology.
650	2	4	_aInternal Medicine.
650	2	4	_aHuman Genetics.
650	2	4	_aMolecular Medicine.
650	2	4	_aHuman Physiology.
700	1		_aKopchick, J. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642111822
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-11183-9
596			_a19
942			_cLIBRO_ELEC
999			_c201837 _d201837