000			03317nam a22004575i 4500
001			u374011
003			SIRSI
005			20160812084213.0
007			cr nn 008mamaa
008			100327s2010 gw | s |||| 0|eng d
020			_a9783642114168 _9978-3-642-11416-8
040			_cMX-MeUAM
050		4	_aRB155-155.8
050		4	_aQH431
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aDakubo, Gabriel D. _eauthor.
245	1	0	_aMitochondrial Genetics and Cancer _h[recurso electrónico] / _cby Gabriel D. Dakubo.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2010.
300			_aX, 368p. 62 illus., 31 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aGeneral Overview of Mitochondrial Genetics and Functions -- Basic Mitochondrial Genetics, Bioenergetics, and Biogenesis -- The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells -- Mitochondrial Control of Apoptosis and Cancer -- Mitochondrial-to-Nuclear Communications in Cancer -- Mitochondrial Genetic Alterations in Cancer -- Types of Mitochondrial Genetic Alterations in Cancer -- Mitochondrial Genetic Alterations in Cancer I -- Mitochondrial Genetic Alterations in Cancer II -- Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer -- Functional Importance of Mitochondrial Genetic Alterations in Cancer -- The Role of Mitochondrial Reactive Oxygen Species in Cancer -- Clinical Applications of Mitochondrial Genome Changes in Cancer -- Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring: The Copy Number Advantage -- Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors -- Analysis of Mitochondrial Genome Alterations in Cancer -- “Mitocans”: Agents Targeting Mitochondria to Kill Cancer Cells.
520			_aThe pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman genetics.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aMolecular Medicine.
650	2	4	_aCancer Research.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642114151
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-11416-8
596			_a19
942			_cLIBRO_ELEC
999			_c201891 _d201891