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008 101013s2010 gw | s |||| 0|eng d
020 _a9783642133329
_9978-3-642-13332-9
040 _cMX-MeUAM
050 4 _aQR355-502
082 0 4 _a616.9101
_223
100 1 _aJohnson, John E.
_eeditor.
245 1 0 _aCell Entry by Non-Enveloped Viruses
_h[recurso electrónico] /
_cedited by John E. Johnson.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2010.
300 _aXIV, 230 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v343
505 0 _aFlock House Virus: A Model System for Understanding Non-Enveloped Virus Entry and Membrane Penetration -- The Caliciviruses -- Picornaviruses -- From Touchdown to Transcription: The Reovirus Cell Entry Pathway -- Rotavirus Cell Entry -- Structures and Functions of Parvovirus Capsids and the Process of Cell Infection -- Cellular Entry of Polyomaviruses -- Adenovirus.
520 _aNon enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. While many aspects of these viruses have been addressed previously, this volume specifically focuses on the issue of their entry into cells, with particular attention to the translocation of the viral genome through a membrane, without the aid of inter-membrane fusion that is common and reasonably well understood in enveloped viruses. Sufficient detail has been revealed in most of the viruses discussed in this volume to establish a credible argument for convergent evolution. A variety of mechanisms are described to generate and tightly control the exposure of a fusion-like peptide or an entire gene product that facilitates membrane permeation and genome delivery into the cytoplasm and, for the DNA viruses, the nucleus. Since there is no viral membrane to fuse with the cellular membrane, the events at this interface are different from those associated with enveloped viruses and with the various fusion events associated with normal cellular function. Thus, while the factors critical for this process to occur have been well established for many of these viruses, a specific mechanism for genome penetration is yet to be determined. We believe that this volume will provide a reference of enduring value for the non enveloped virus field and our hope is that the focus on entry and genome translocation across a cellular membrane will stimulate new ideas and mechanistic studies of this critically important process.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical virology.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642133312
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v343
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-13332-9
596 _a19
942 _cLIBRO_ELEC
999 _c202343
_d202343