000 | 02959nam a22003855i 4500 | ||
---|---|---|---|
001 | u374830 | ||
003 | SIRSI | ||
005 | 20160812084254.0 | ||
007 | cr nn 008mamaa | ||
008 | 101013s2011 gw | s |||| 0|eng d | ||
020 |
_a9783642146916 _9978-3-642-14691-6 |
||
040 | _cMX-MeUAM | ||
050 | 4 | _aQA276-280 | |
082 | 0 | 4 |
_a519.5 _223 |
100 | 1 |
_aNauta, Jozef. _eauthor. |
|
245 | 1 | 0 |
_aStatistics in Clinical Vaccine Trials _h[recurso electrónico] / _cby Jozef Nauta. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2011. |
|
300 |
_aXVIII, 153 p. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
505 | 0 | _aBasic Concepts of Vaccine Immunology -- Humoral and Cellular Immunity -- Standard Statistical Methods for the Analysis of Immunogenicity Data -- Antibody Titres and Two Types of Bias -- Adjusting for Imbalance in Pre-vaccination State -- Vaccine Equivalence and Non-Inferiority Immunogenicity Trials -- Vaccine Field Efficacy Trials -- Correlates of Protection -- Safety of Vaccines -- Appendices: SAS and Floating Point Format for Calculated Variables -- Closed-Form Solutions for the Constrained ML Estimators Ro -- Simulation Results on Jewell’s Correction for the Rate Ratio -- Proof of Inequality -- A Generalized Worst-Case Sensitivity Analysis for a Single Seroresponse Rate for Which the Confidence Interval Must Fall Above a Pre-Specified Bound. | |
520 | _aThis monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data. | ||
650 | 0 | _aStatistics. | |
650 | 1 | 4 | _aStatistics. |
650 | 2 | 4 | _aStatistics, general. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642146909 |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-14691-6 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c202710 _d202710 |