000			02989nam a22004215i 4500
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007			cr nn 008mamaa
008			110426s2011 gw | s |||| 0|eng d
020			_a9783642160172 _9978-3-642-16017-2
040			_cMX-MeUAM
050		4	_aRC261-271
082	0	4	_a614.5999 _223
100	1		_aKarin, Michael. _eeditor.
245	1	0	_aNF-kB in Health and Disease _h[recurso electrónico] / _cedited by Michael Karin.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011.
300			_aVIII, 268 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v349
505	0		_aPreface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-?B and mucosal homeostasis -- NF-kappaB In liver cancer – the plot thickens -- Subject index.
520			_aThis volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.
650		0	_aMedicine.
650		0	_aOncology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642160165
830		0	_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v349
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-16017-2
596			_a19
942			_cLIBRO_ELEC
999			_c203078 _d203078