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005 | 20160812084312.0 | ||
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008 | 110426s2011 gw | s |||| 0|eng d | ||
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_a9783642160172 _9978-3-642-16017-2 |
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040 | _cMX-MeUAM | ||
050 | 4 | _aRC261-271 | |
082 | 0 | 4 |
_a614.5999 _223 |
100 | 1 |
_aKarin, Michael. _eeditor. |
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245 | 1 | 0 |
_aNF-kB in Health and Disease _h[recurso electrónico] / _cedited by Michael Karin. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011. |
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300 |
_aVIII, 268 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v349 |
|
505 | 0 | _aPreface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-?B and mucosal homeostasis -- NF-kappaB In liver cancer – the plot thickens -- Subject index. | |
520 | _aThis volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642160165 |
830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v349 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-16017-2 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c203078 _d203078 |