000			02833nam a22004695i 4500
001			u375341
003			SIRSI
005			20160812084319.0
007			cr nn 008mamaa
008			110215s2011 gw | s |||| 0|eng d
020			_a9783642165559 _9978-3-642-16555-9
040			_cMX-MeUAM
050		4	_aQH573-671
082	0	4	_a571.6 _223
100	1		_aMecham, Robert P. _eeditor.
245	1	4	_aThe Extracellular Matrix: an Overview _h[recurso electrónico] / _cedited by Robert P. Mecham.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011.
300			_aXIV, 426 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiology of Extracellular Matrix
505	0		_aAn overview of extracellular matrix structure and function --  Fibronectin and other adhesive glycoproteins --  Collagen: suprastructures and collagen fibril assembly.-  Asement membrane; Hyaluronan and the Aggregating Proteoglycans -- The small, leucine-rich proteoglycans -- Microfibrils and fibrillin -- Elastin -- Lysyl oxidase and lysyl oxidase-like enzymes -- The Fibulins -- Matricellular proteins.
520			_aKnowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
650		0	_aLife sciences.
650		0	_aMedicine.
650		0	_aBiochemistry.
650		0	_aCytology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aProtein Science.
650	2	4	_aMolecular Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642165542
830		0	_aBiology of Extracellular Matrix
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-16555-9
596			_a19
942			_cLIBRO_ELEC
999			_c203221 _d203221