000 | 02367nam a22004695i 4500 | ||
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001 | u375427 | ||
003 | SIRSI | ||
005 | 20160812084323.0 | ||
007 | cr nn 008mamaa | ||
008 | 110201s2011 gw | s |||| 0|eng d | ||
020 |
_a9783642169311 _9978-3-642-16931-1 |
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040 | _cMX-MeUAM | ||
050 | 4 | _aQD433-436 | |
082 | 0 | 4 |
_a572.84 _223 |
100 | 1 |
_aDavidovich, Chen. _eauthor. |
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245 | 1 | 0 |
_aTargeting Functional Centers of the Ribosome _h[recurso electrónico] / _cby Chen Davidovich. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011. |
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300 |
_aXIV, 74 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 | _aSpringer Theses | |
505 | 0 | _aIntroduction -- Methods -- Results -- Discussion. | |
520 | _aThis thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. | ||
650 | 0 | _aLife sciences. | |
650 | 0 | _aChemistry, Organic. | |
650 | 0 | _aNucleic acids. | |
650 | 0 | _aBiochemistry. | |
650 | 1 | 4 | _aLife Sciences. |
650 | 2 | 4 | _aNucleic Acid Chemistry. |
650 | 2 | 4 | _aProtein Science. |
650 | 2 | 4 | _aOrganic Chemistry. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642169304 |
830 | 0 | _aSpringer Theses | |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-16931-1 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c203307 _d203307 |