000			02803nam a22004815i 4500
001			u375538
003			SIRSI
005			20160812084328.0
007			cr nn 008mamaa
008			110502s2011 gw | s |||| 0|eng d
020			_a9783642175756 _9978-3-642-17575-6
040			_cMX-MeUAM
050		4	_aQH506
082	0	4	_a611.01816 _223
100	1		_aTripathi, Onkar N. _eeditor.
245	1	0	_aHeart Rate and Rhythm _h[recurso electrónico] : _bMolecular Basis, Pharmacological Modulation and Clinical Implications / _cedited by Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011.
300			_aXXII, 678 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aNormal Cardiac Rhythm and Pacemaker Activity -- Modeling of Rhythm in the Heart -- Cardiac Development and Anatomy -- Mechanisms of Acquired Arrhythmia -- Mechanisms of Inherited Arrhythmia -- Role of Specific Channels and Transporters in Arrhythmia -- Drugs and Cardiac Arrhythmia.
520			_aPathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aToxicology.
650		0	_aCardiology.
650	1	4	_aBiomedicine.
650	2	4	_aMolecular Medicine.
650	2	4	_aHuman Physiology.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aCardiology.
700	1		_aRavens, Ursula. _eeditor.
700	1		_aSanguinetti, Michael C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642175749
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-17575-6
596			_a19
942			_cLIBRO_ELEC
999			_c203418 _d203418