| 000 | 02597nam a22004215i 4500 | ||
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| 001 | u376143 | ||
| 003 | SIRSI | ||
| 005 | 20160812084358.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110804s2011 gw | s |||| 0|eng d | ||
| 020 |
_a9783642208201 _9978-3-642-20820-1 |
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| 040 | _cMX-MeUAM | ||
| 050 | 4 | _aQH324.2-324.25 | |
| 082 | 0 | 4 |
_a570.285 _223 |
| 100 | 1 |
_aPrinz, Heino. _eauthor. |
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| 245 | 1 | 0 |
_aNumerical Methods for the Life Scientist _h[recurso electrónico] : _bBinding and Enzyme Kinetics Calculated with GNU Octave and MATLAB / _cby Heino Prinz. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2011. |
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| 300 |
_aIX, 149p. 61 illus., 52 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 505 | 0 | _aPreparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches. . | |
| 520 | _aEnzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered. | ||
| 650 | 0 | _aLife sciences. | |
| 650 | 0 | _aBioinformatics. | |
| 650 | 1 | 4 | _aLife Sciences. |
| 650 | 2 | 4 | _aBioinformatics. |
| 650 | 2 | 4 | _aComputational Biology/Bioinformatics. |
| 650 | 2 | 4 | _aMathematical and Computational Biology. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642208195 |
| 856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-20820-1 |
| 596 | _a19 | ||
| 942 | _cLIBRO_ELEC | ||
| 999 |
_c204023 _d204023 |
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