000			03573nam a22005175i 4500
001			u377000
003			SIRSI
005			20160812084441.0
007			cr nn 008mamaa
008			110711s2011 au | s |||| 0|eng d
020			_a9783709107331 _9978-3-7091-0733-1
040			_cMX-MeUAM
050		4	_aQR1-502
082	0	4	_a660.62 _223
100	1		_aKnirel, Yuriy A. _eeditor.
245	1	0	_aBacterial Lipopolysaccharides _h[recurso electrónico] : _bStructure, Chemical Synthesis, Biogenesis and Interaction with Host Cells / _cedited by Yuriy A. Knirel, Miguel A. Valvano.
264		1	_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2011.
300			_aXI, 440 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a-1. Lipid A structure (A. Silipo, A. Molinaro) -- 2. Structure of the lipopolysaccharide core region (O. Holst) -- 3. Structure of O-antigens (Y.A. Knirel) -- 4. Chemical synthesis of lipid A and analogues (S. Kusumoto) -- 5. Chemical synthesis of lipopolysaccharide core (P. Kosma, A. Zamyatina) -- 6. Genetics and biosynthesis of lipid A (C.M. Stead, A.C. Pride, M.S. Trent) -- 7. Pathways for the biosynthesis of NDP sugars (Y. Hao, J. Lam) -- 8. Lipopolysaccharide core oligosaccharide biosynthesis and assembly (U. Mamat, M. Skurnik, J.A. Bengoechea) -- 9. Genetics, biosynthesis and assembly of O-antigen (M.A. Valvano, S.E. Furlong, K.B. Patel) -- 10. Lipopolysaccharide export to the outer membrane (P. Sperandeo, G. Dehò, A. Polissi) -- 11. Evolution of lipopolysaccharide biosynthesis genes (M.M. Cunneen, P.R. Reeves) -- 12. The molecular basis of lipid A and Toll-like receptor 4 interactions (G.L. Hold, C.E. Bryant) -- 13. Modulation of lipopolysaccharide signalling through TLR4 agonists and antagonists (F. Peri, M. Piazza, V. Calabrese, R. Cighetti) -- 14. Lipopolysaccharide interactions with plants (G. Erbs, M.-A. Newman).
520			_aThe bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.
650		0	_aChemistry.
650		0	_aImmunology.
650		0	_aToxicology.
650		0	_aMicrobiology.
650		0	_aCarbohydrates.
650		0	_aBiochemistry.
650	1	4	_aChemistry.
650	2	4	_aApplied Microbiology.
650	2	4	_aImmunology.
650	2	4	_aMedical Biochemistry.
650	2	4	_aCarbohydrate Chemistry.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aMedicinal Chemistry.
700	1		_aValvano, Miguel A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783709107324
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-7091-0733-1
596			_a19
942			_cLIBRO_ELEC
999			_c204880 _d204880