| 000 | 02507nam a22004935i 4500 | ||
|---|---|---|---|
| 001 | u377019 | ||
| 003 | SIRSI | ||
| 005 | 20160812084442.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 101029s2011 sz | s |||| 0|eng d | ||
| 020 |
_a9783764389482 _9978-3-7643-8948-2 |
||
| 040 | _cMX-MeUAM | ||
| 050 | 4 | _aRC254-282 | |
| 082 | 0 | 4 |
_a616.994 _223 |
| 100 | 1 |
_aGhobrial, Irene M. _eeditor. |
|
| 245 | 1 | 0 |
_aBortezomib in the Treatment of Multiple Myeloma _h[recurso electrónico] / _cedited by Irene M. Ghobrial, Paul G. Richardson, Kenneth C. Anderson. |
| 264 | 1 |
_aBasel : _bSpringer Basel : _bImprint: Springer, _c2011. |
|
| 300 |
_aVIII, 179p. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 | _aMilestones in Drug Therapy | |
| 520 | _aMultiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aOncology. | |
| 650 | 0 | _aToxicology. | |
| 650 | 0 | _aCytology. | |
| 650 | 1 | 4 | _aMedicine & Public Health. |
| 650 | 2 | 4 | _aOncology. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 650 | 2 | 4 | _aApoptosis. |
| 700 | 1 |
_aRichardson, Paul G. _eeditor. |
|
| 700 | 1 |
_aAnderson, Kenneth C. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783764389475 |
| 830 | 0 | _aMilestones in Drug Therapy | |
| 856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-7643-8948-2 |
| 596 | _a19 | ||
| 942 | _cLIBRO_ELEC | ||
| 999 |
_c204899 _d204899 |
||