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020			_a9789048193554 _9978-90-481-9355-4
040			_cMX-MeUAM
050		4	_aQH345
050		4	_aQD415-436
082	0	4	_a572 _223
100	1		_aOwens, Raymond. _eeditor.
245	1	0	_aFunctional and Structural Proteomics of Glycoproteins _h[recurso electrónico] / _cedited by Raymond Owens, Joanne Nettleship.
264		1	_aDordrecht : _bSpringer Netherlands, _c2011.
300			_aX, 181 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- Glycoproteomics in Health and Disease, W.B. Struwe et al. -- Glyco-engineering of Fc Glycans to the Biological Functions in Therapeutic IgGs, T. Shantra Raju et al. -- Bioinformatics Databases and Applications Available for Glycobiology and Glycomics, R. Ranzinger et al. -- Lectin Microarrays: simple tools for the analysis of complex glycans, L. Krishnamoorthy and L.K. Mahal -- The Application of High Throughput Mass Spectrometry to the Analysis of Glycoproteins, S. Singh et al. -- Solutions to the Glycosylation Problem for Low- and High-Throughput Structural Glycoproteomics, S.J. Davis and M. Crispin -- Role of Glycoproteins in Virus-Human Cell Interactions, T.A. Bowden and E.E. Fry -- Subject Index.
520			_aIt has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.
650		0	_aLife sciences.
650		0	_aBiochemistry.
650	1	4	_aLife Sciences.
650	2	4	_aBiochemistry, general.
700	1		_aNettleship, Joanne. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789048193547
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-90-481-9355-4
596			_a19
942			_cLIBRO_ELEC
999			_c205865 _d205865