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007			cr nn 008mamaa
008			110329s2011 ne | s |||| 0|eng d
020			_a9789400707504 _9978-94-007-0750-4
040			_cMX-MeUAM
050		4	_aR-RZ
082	0	4	_a610 _223
100	1		_aBrakebusch, Cord. _eeditor.
245	1	0	_aMouse as a Model Organism _h[recurso electrónico] : _bFrom Animals to Cells / _cedited by Cord Brakebusch, Taina Pihlajaniemi.
264		1	_aDordrecht : _bSpringer Netherlands, _c2011.
300			_aXIV, 165 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- 1 Genomic insulators in transgenic animals, Lluís Montoliu et al -- 2 The GERMAN MOUSE CLINIC – Running an open access platform, Martin Hrabé de Angelis et al. -- 3 Nature & Nurture: impacts on mouse phenotypes & translational research, Cory Brayton -- 4 X The informatics of high-throughput mouse phenotyping: EUMODIC and beyond, John M Hancock and Hilary Gates -- 5 Experimental tumour models in mice, Ritva Heljasvaara and Taina Pihlajaniemi -- 6 Exploration of MMP function in mouse models of angiogenesis, Agnès NOEL et al. -- 7 Tumor- stroma interactions: focus on fibroblasts, Donald Gullberg and Rolf K. Reed -- 8 Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts, Olivier De Wever et al. -- 9 Systemic Instigation: A Mouse Model to Study Breast Cancer as a Systemic Disease, Sandra S. McAllister -- Index.
520			_aCell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.
650		0	_aMedicine.
650		0	_aAnimal genetics.
650		0	_aTransgenic organisms.
650		0	_aLaboratory animals.
650		0	_aCytology _xResearch_xMethodology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aAnimal Models.
650	2	4	_aAnimal Genetics and Genomics.
650	2	4	_aBiological Techniques.
650	2	4	_aTransgenics.
700	1		_aPihlajaniemi, Taina. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400707498
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-94-007-0750-4
596			_a19
942			_cLIBRO_ELEC
999			_c206278 _d206278