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005			20160812084558.0
007			cr nn 008mamaa
008			110823s2011 ne | s |||| 0|eng d
020			_a9789400715677 _9978-94-007-1567-7
040			_cMX-MeUAM
050		4	_aRC261-271
082	0	4	_a614.5999 _223
100	1		_aCesario, Alfredo. _eeditor.
245	1	0	_aCancer Systems Biology, Bioinformatics and Medicine _h[recurso electrónico] : _bResearch and Clinical Applications / _cedited by Alfredo Cesario, Frederick Marcus.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2011.
300			_aXXVIII, 484 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPART I – Introduction and background -- 1. Introduction to systems approaches to cancer -- 2. Cancer: clinical background and key challenges -- PART II – Laboratory, clinical, data and educational resources -- 3. Global molecular and cellular measurement technologies -- 4. Cell lines, tissue samples, model organisms, biobanks -- 5. Expression and genetic variation databases for cancer research -- 6. Education and Research Infrastructures -- PART III – Bioinformatics and systems biology analysis -- 7. Mathematical tools in cancer signalling systems biology -- 8. Computational tools for systems biology -- 9. The hallmarks of cancer revisited through systems biology and network modeling -- 10. Systems biology analysis of cell death pathways in cancer: how collaborative and interdisciplinary research helps -- 11. Systems biology, bioinformatics and medicine approaches to cancer progression outcomes -- 12. System dynamics at the physiological and tumour level -- PART IV – Diagnosis, clinical and treatment applications -- 13. Diagnostic and prognostic cancer biomarkers: from traditional to systems approaches -- 14. Systems biology approaches to cancer drug development -- 15. Circadian rhythms and cancer chronotherapeutics -- 16. Clinical applications of systems approaches -- 17. Cancer robustness and therapy strategies -- PART V – Perspectives and conclusions -- 18. Synthetic biology and perspectives -- 19. Conclusions -- Index.
520			_aThis teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods.  Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aMicrobiology.
650		0	_aBioinformatics.
650		0	_aBiological models.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aSystems Biology.
650	2	4	_aOncology.
650	2	4	_aMedical Microbiology.
650	2	4	_aComputational Biology/Bioinformatics.
700	1		_aMarcus, Frederick. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400715660
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-94-007-1567-7
596			_a19
942			_cLIBRO_ELEC
999			_c206420 _d206420