000			03406cam a2200445Mi 4500
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006			m o d
007			cr |n|||||||||
008			140222s2014 vtu o 000 0 eng d
040			_aEBLCP _beng _epn _cEBLCP _dOCLCQ _dOPELS _dNT _dYDXCP _dUIU _dOCLCQ _dOCLCO _dOCLCQ
020			_a9780128004982 _q(electronic bk.)
020			_a0128004983 _q(electronic bk.)
029	1		_aDEBSZ _b414272064
029	1		_aNLGGC _b37319269X
050		4	_aRD261
082	0	4	_a617.092
049			_aTEFA
100	1		_aKozlov, Andrei P.
245	1	0	_aEvolution by tumor neofunctionalization _h[recurso electrónico] : _bthe role of tumors in the origin of new cell types, tissues and organs / _cby Andrei P. Kozlov.
260			_aBurlington : _bElsevier Science, _c2014.
300			_a1 online resource (248 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
505	0		_a1. The modern synthesis of evolutionary biology and the health sciences -- 2. Evolution and pathology -- 3. The widespread occurrences of tumors in multicellular organisms -- 4. Features of tumors that could be used in evolution -- 5. Tumors might participate in the evolution of ontogenesis -- 6. Tumors that might play a role in evolution -- 7. Tumors that have played a role in evolution -- 8. The general principles and molecular mechanism in the orgin of novel genes -- 9. The origin of evolutionary novel genes and the evolution of new functions and structural complexity of multicellular organisms -- 10. The orgin of new cell types, tissues and organs by tumor neofunctionalization -- 11. Experimental confirmation of nontrivial predictions of evolution by the tumor neofunctionalization hypothesis -- 12. Other evidence supporting the positive evolutionary role of tumors and the hypothesis of evolution by tumor neofunctionalization.
520			_aEvolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution.
588	0		_aPrint version record.
650		0	_aTumors _xMolecular aspects.
650		0	_aEvolution (Biology)
650		4	_aTumors.
650		7	_aMEDICAL _xSurgery _xGeneral. _2bisacsh
655		4	_aElectronic books.
776	0	8	_iPrint version: _aKozlov, Andrei P. _tEvolution by Tumor Neofunctionalization : The Role of Tumors in the Origin of New Cell Types, Tissues and Organs. _dBurlington : Elsevier Science, 2014 _z9780128001653
856	4	0	_zLibro electrónico _3ScienceDirect _uhttp://148.231.10.114:2048/login?url=http://www.sciencedirect.com/science/book/9780128001653
596			_a19
942			_cLIBRO_ELEC
999			_c206989 _d206989