000 03588nam a22004695i 4500
001 978-981-10-1498-7
003 DE-He213
005 20180206183006.0
007 cr nn 008mamaa
008 160704s2016 si | s |||| 0|eng d
020 _a9789811014987
_9978-981-10-1498-7
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 4 _aThe Long and Short Non-coding RNAs in Cancer Biology
_h[recurso electrónico] /
_cedited by Erwei Song.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2016.
300 _aVIII, 458 p. 21 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v927
505 0 _aNon-coding RNAs: New Players in Cancers -- The Working Modules of Long Non-coding RNAs in Cancer Cells -- Methods to Study Long Non-coding RNA Biology in Cancer -- Relationship between Non-coding RNA Dysregulation and Epigenetic Mechanisms in Cancer -- Non-coding RNAs in Growth and Death of Cancer Cells -- Non-coding RNAs in Cancer Cell Plasticity -- Non-coding RNAs in Regulation of Cancer Metabolic Reprogramming -- Non-coding RNAs in Tumor Angiogenesis -- Non-coding RNAs in Cancer Immunity -- Non-coding RNAs in Therapeutic Resistance of Cancer -- Non-coding RNAs Regulating Cancer Signaling Network -- Non-coding RNAs Regulating NFkB Signaling -- Non-coding RNAs Regulating p53 and c-Myc Signaling -- Viral Non-coding RNAs in Cancer Biology -- Non-coding RNAs in Cancer Diagnosis -- Therapeutic Potentials of Non-coding RNAs: Targeted Delivery of NcRNAs in Cancer Cells.
520 _aThe book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
700 1 _aSong, Erwei.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789811014963
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v927
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-981-10-1498-7
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c226114
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