000			03853nam a22005055i 4500
001			978-3-319-23793-0
003			DE-He213
005			20180206183012.0
007			cr nn 008mamaa
008			151217s2016 gw | s |||| 0|eng d
020			_a9783319237930 _9978-3-319-23793-0
050		4	_aQP34-38
072		7	_aMFG _2bicssc
072		7	_aMED075000 _2bisacsh
082	0	4	_a612 _223
245	1	0	_aOrganic Cation Transporters _h[recurso electrónico] : _bIntegration of Physiology, Pathology, and Pharmacology / _cedited by Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter.
250			_a1st ed. 2016.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aXV, 264 p. 34 illus., 14 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction to the cellular transport of organic cations -- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism -- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity -- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy -- Physiological and pathological regulation of transporters for organic cations -- Endocrine and metabolic regulation of transporters for organic cations -- Organic cation transporters (OCTs) as modulators of behavior and mood -- Organic cation transporters as modulators of neurodegeneration and neuroprotection -- Translational relevance of animal models for the study of organic cation transporter function -- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.
520			_aThis innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aPharmacology.
650		0	_aPathology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Physiology.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aPathology.
700	1		_aCiarimboli, Giuliano. _eeditor.
700	1		_aGautron, Sophie. _eeditor.
700	1		_aSchlatter, Eberhard. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319237923
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-23793-0
912			_aZDB-2-SBL
942			_cLIBRO_ELEC
999			_c226219 _d226219