000 03442nam a22004935i 4500
001 978-3-319-34148-4
003 DE-He213
005 20180206183015.0
007 cr nn 008mamaa
008 160809s2016 gw | s |||| 0|eng d
020 _a9783319341484
_9978-3-319-34148-4
050 4 _aR857.T55
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a612.028
_223
082 0 4 _a571.538
_223
245 1 0 _aGenome Editing
_h[recurso electrónico] /
_cedited by Kursad Turksen.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aIX, 166 p. 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aGenome Editing with Targetable Nucleases -- CRISPR/Cas9 Approaches to Investigate the Non-coding Genome -- At the Conflux of Human Genome Engineering and Induced Pluripotency -- CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies -- Genome Editing Technology in CRISPR/Cas System: How to Increase Knock-in Efficiency in Mouse Zygotes -- Developments in the Generation of Reporter Stem Cells -- Current Status of Genome Editing in Cardiovascular Medicine -- Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellitus -- Genome Editing in the Retina: a Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model -- Index.
520 _aThis timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
650 0 _aLife sciences.
650 0 _aStem cells.
650 0 _aRegenerative medicine.
650 0 _aTissue engineering.
650 0 _aAnimal genetics.
650 1 4 _aLife Sciences.
650 2 4 _aRegenerative Medicine/Tissue Engineering.
650 2 4 _aStem Cells.
650 2 4 _aAnimal Genetics and Genomics.
700 1 _aTurksen, Kursad.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319341460
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-34148-4
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c226276
_d226276