000			03319nam a22005295i 4500
001			978-94-024-0921-5
003			DE-He213
005			20180206183017.0
007			cr nn 008mamaa
008			161012s2016 ne | s |||| 0|eng d
020			_a9789402409215 _9978-94-024-0921-5
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
245	1	0	_aRegulation of Cytokine Gene Expression in Immunity and Diseases _h[recurso electrónico] / _cedited by Xiaojing Ma.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2016.
300			_aVIII, 225 p. 23 illus., 22 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v941
505	0		_aRegulation of IFN-? expression -- Regulation of The interleukin-1 family -- Regulation of IL-4 Expression in Immunity and Diseases -- Regulation of IL-6 in immunity and diseases -- Regulation of Interleukin-10 Expression -- Regulation of Interleukin-12 Production in Antigen-Presenting Cells -- Regulation of Interleukin-17 production -- Regulation of interleukin-23 expression in health and disease -- Regulation and immune function of IL-27 -- The immunobiology of Interleukin-35 and its regulation and gene expression.
520			_aThis book explores the major cytokines, such as IL-1 and IFN-?, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
650		0	_aMedicine.
650		0	_aGene expression.
650		0	_aImmunology.
650		0	_aCytokines.
650		0	_aGrowth factors.
650		0	_aCell biology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aGene Expression.
650	2	4	_aCytokines and Growth Factors.
650	2	4	_aCell Biology.
700	1		_aMa, Xiaojing. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789402409192
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v941
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-94-024-0921-5
912			_aZDB-2-SBL
942			_cLIBRO_ELEC
999			_c226325 _d226325