000			04053nam a22004815i 4500
001			978-3-319-42023-3
003			DE-He213
005			20180206183018.0
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008			161013s2016 gw | s |||| 0|eng d
020			_a9783319420233 _9978-3-319-42023-3
050		4	_aRC261-271
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082	0	4	_a614.5999 _223
245	1	0	_aSystems Biology of Tumor Microenvironment _h[recurso electrónico] : _bQuantitative Modeling and Simulations / _cedited by Katarzyna A. Rejniak.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aXVII, 249 p. 93 illus., 80 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v936
505	0		_aForeword -- Preface -- List of Contributors -- Image Analysis of the Tumor Microenvironment -- Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach -- Computer Simulations of the Tumor Vasculature: Applications to Interstitial Fluid Flow, Drug Delivery, and Oxygen -- Cell-ECM Interactions in Tumor Invasion -- Circulating Tumor Cells: When Solid tumor Meets Fluid Microenvironment -- Modeling Proteolytically Driven Tumor Lymphangiogenesis -- Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction -- Microenvironmental Niches and Sanctuaries: a Route to Acquired Resistance -- The Tumor Microenvironment as a Barrier to Cancer Nanotherapy -- Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs -- Optimizing Chemotherapeutic Anti-Cancer Treatment and the Tumor Microenvironment: An Analysis of Mathematical Models -- Progress towards computational 3-D multicellular systems biology -- Index.
520			_aThis edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aBiomathematics.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aMathematical and Computational Biology.
650	2	4	_aBiological and Medical Physics, Biophysics.
700	1		_aRejniak, Katarzyna A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319420219
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v936
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-42023-3
912			_aZDB-2-SBL
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