000 02978nam a22004455i 4500
001 978-3-319-25616-0
003 DE-He213
005 20180206183026.0
007 cr nn 008mamaa
008 160112s2016 gw | s |||| 0|eng d
020 _a9783319256160
_9978-3-319-25616-0
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aHypertension and the Brain as an End-Organ Target
_h[recurso electrónico] /
_cedited by Hélène Girouard.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aXIX, 221 p. 24 illus., 20 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aA systematic review of reviews to examine the association between hypertension and cognitive impairments in adults -- Hypertension and age-related cognitive decline -- Hypertension and stroke -- Neuroimaging as a research tool in human essential hypertension -- Cognitive Dysfunction and Dementia in animal models of hypertension -- The effects of hypertension on cerebral artery structure and function, and cerebral blood flow -- Arterial stiffness and the brain -- Endothelium, the blood-brain barrier, and hypertension -- Hypertension and brain inflammation: role of RAS-induced glial activation -- Sex differences in neural regulation of hypertension.
520 _aThe first comprehensive overview of the effects ofhypertension on the brain. The book discusses not only the relationship betweenhypertension and stroke, but also the much less studied relationshipbetween hypertension and cognitive decline and neurodegenerativediseases such as Alzheimer's. It seeks to answer two important questions. First, what are the conditions under which hypertension is associated with stroke, cognitivedecline, and neurodegenerative disease? And second, what are thebiological mechanisms by which hypertension alters brain homeostasis? By looking at the biological mechanisms ofthese relationships, this book provides insight to neuroscientists andneurologists regarding why anti-hypertension treatments make a bigdifference in the case of stroke, but have very little impact on cognitivedecline and brain aging.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aNeurology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aNeurology.
700 1 _aGirouard, Hélène.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319256146
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-25616-0
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c226502
_d226502