000			03318nam a22004455i 4500
001			978-3-319-46505-0
003			DE-He213
005			20180206183058.0
007			cr nn 008mamaa
008			161128s2016 gw | s |||| 0|eng d
020			_a9783319465050 _9978-3-319-46505-0
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aResistance to Targeted Therapies Against Adult Brain Cancers _h[recurso electrónico] / _cedited by Amanda Tivnan.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aXVI, 260 p. 19 illus., 16 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResistance to Targeted Anti-Cancer Therapeutics, _x2196-5501
505	0		_aTargeted therapies in gliomas: An overview -- Targeting chemotherapy resistance in glioblastoma through modulation of ABC transporters -- Resistance of Glioblastomas to Radiation Therapy -- The blood-brain barrier in glioblastoma multiforme: Pathology and therapeutic implications -- Resistance of brain tumours to small-molecule targeted therapies: lessons from various cancer types -- Drug repurposing to circumvent chemotherapy resistance in brain tumours -- Small molecule inhibitors in glioblastoma: Key pathways and resistance mechanisms -- Imaging Targeted Therapy Response and Resistance in Glioblastoma -- Drug Resistance in Malignant Meningiomas -- Recurrence of Low-Grade Glioma - Have the Targeted Therapies Improved for Better Outcomes? -- Host-Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance.
520			_aThis volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
650		0	_aMedicine.
650		0	_aCancer research.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
700	1		_aTivnan, Amanda. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319465043
830		0	_aResistance to Targeted Anti-Cancer Therapeutics, _x2196-5501
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-46505-0
912			_aZDB-2-SBL
942			_cLIBRO_ELEC
999			_c227098 _d227098