000			03293nam a22005055i 4500
001			978-3-319-27111-8
003			DE-He213
005			20180206183107.0
007			cr nn 008mamaa
008			160404s2016 gw | s |||| 0|eng d
020			_a9783319271118 _9978-3-319-27111-8
050		4	_aQD433-436
072		7	_aPSB _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.84 _223
245	1	0	_aModified Nucleic Acids _h[recurso electrónico] / _cedited by Kazuhiko Nakatani, Yitzhak Tor.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aX, 276 p. 162 illus., 62 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aNucleic Acids and Molecular Biology, _x0933-1891 ; _v31
505	0		_aEmissive 5-Substituted Uridine Analogues -- Fluorescent purine nucleosides and their applications -- Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids -- Synthetic wavelength-shifting fluorescent probes of nucleic acids -- DNA Assisted Multichromophore Assembly -- Polymerase Synthesis of Base-Modified DNA -- Photo-cross-linking Reaction in Nucleic Acids ? Chemistry and Applications -- Site-Directed Spin Labeling for EPR Studies of Nucleic Acids -- Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site -- 2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA -- Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine -- Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.
520			_aThis book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
650		0	_aLife sciences.
650		0	_aBiochemical engineering.
650		0	_aNucleic acids.
650		0	_aCell biology.
650	1	4	_aLife Sciences.
650	2	4	_aNucleic Acid Chemistry.
650	2	4	_aCell Biology.
650	2	4	_aBiochemical Engineering.
700	1		_aNakatani, Kazuhiko. _eeditor.
700	1		_aTor, Yitzhak. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319271095
830		0	_aNucleic Acids and Molecular Biology, _x0933-1891 ; _v31
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-27111-8
912			_aZDB-2-SBL
942			_cLIBRO_ELEC
999			_c227275 _d227275