000			03106nam a22005415i 4500
001			978-3-319-30237-9
003			DE-He213
005			20180206183127.0
007			cr nn 008mamaa
008			160301s2016 gw | s |||| 0|eng d
020			_a9783319302379 _9978-3-319-30237-9
050		4	_aR856-857
072		7	_aMQW _2bicssc
072		7	_aTEC009000 _2bisacsh
082	0	4	_a610.28 _223
100	1		_aFrega, Monica. _eauthor.
245	1	0	_aNeuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems _h[recurso electrónico] / _cby Monica Frega.
250			_a1st ed. 2016.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aXIII, 148 p. 97 illus., 43 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053
505	0		_aIntroduction -- Dissociated Neuronal Networks Coupled to Micro-Electrode Arrays Devices -- In Vitro Neuronal Networks -- 3D Neuronal Networks: State of the Art -- 3D Neuronal Networks Coupled to MEAs -- Neuro-pharmacological Studies -- Discussion and Conclusion -- Data Analysis.
520			_aThe book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems. < .
650		0	_aEngineering.
650		0	_aNeurosciences.
650		0	_aCell physiology.
650		0	_aElectronics.
650		0	_aMicroelectronics.
650		0	_aBiomedical engineering.
650	1	4	_aEngineering.
650	2	4	_aBiomedical Engineering.
650	2	4	_aCell Physiology.
650	2	4	_aElectronics and Microelectronics, Instrumentation.
650	2	4	_aNeurosciences.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319302362
830		0	_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-30237-9
912			_aZDB-2-ENG
942			_cLIBRO_ELEC
999			_c227660 _d227660