000 04373nam a22004935i 4500
001 978-3-319-30654-4
003 DE-He213
005 20180206183132.0
007 cr nn 008mamaa
008 160510s2016 gw | s |||| 0|eng d
020 _a9783319306544
_9978-3-319-30654-4
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aCancer and Zebrafish
_h[recurso electrónico] :
_bMechanisms, Techniques, and Models /
_cedited by David M. Langenau.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aXII, 552 p. 85 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v916
505 0 _aPart 1. Powers Of The Zebrafish Model -- 1. Uncharted Waters: Zebrafish Cancer Models Navigate A Course for Oncogene Discovery -- 2. The Toolbox for Conditional Zebrafish Cancer Models -- 3. Approaches to Inactivate Genes in Zebrafish -- 4. Tumor Suppressors in Zebrafish: From Tp53 To Pten and Beyond -- 5. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish -- 6. Genomic Approaches To Zebrafish Cancer -- 7. Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery -- 8. Zebrafish Discoveries in Cancer Epigenetics -- 9. Lymphatics, Cancer and Zebrafish -- 10. In Vivo Imaging of Cancer in Zebrafish -- 11. Imaging Cancer Angiogenesis and Metastasis in A Zebrafish Embryo Model -- 12. Allograft Cancer Cell Transplantation in Zebrafish -- 13. The Zebrafish Xenograft Platform: Evolution of A Novel Cancer Model and Preclinical Screening Tool -- 14. Automation of Technology for Cancer Research -- Part 2. Cancer Models in Fish -- 15. Zebrafish Models Of Human Leukemia: Technological Advances and Mechanistic Insights -- 16. Zebrafish Rhabdomyosarcoma -- 17. Baiting for Cancer: Using The Zebrafish as A Model in Liver And Pancreatic Cancer -- 18. How Zebrafish Are Helping Us To Target Colorectal Cancer -- 19. Zebrafish Melanoma -- 20. Neuroblastoma and Its Zebrafish Model -- 21. Zebrafish Germ Cell Tumors -- 22. Malignant Peripheral Nerve Sheath Tumors -- 23. Xiphophorus and Medaka Cancer Models.
520 _aThis volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aMedical genetics.
650 0 _aAnimal anatomy.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aGene Function.
650 2 4 _aAnimal Anatomy / Morphology / Histology.
700 1 _aLangenau, David M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319306520
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v916
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-30654-4
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c227768
_d227768