000			03755nam a22005055i 4500
001			978-3-319-33913-9
003			DE-He213
005			20180206183135.0
007			cr nn 008mamaa
008			160922s2016 gw | s |||| 0|eng d
020			_a9783319339139 _9978-3-319-33913-9
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aTranslational Neuropsychopharmacology _h[recurso electrónico] / _cedited by Trevor W. Robbins, Barbara J. Sahakian.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016.
300			_aXII, 498 p. 124 illus., 92 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Behavioral Neurosciences, _x1866-3370 ; _v28
505	0		_aTranslational mouse models of autism; Advancing towards pharmacological therapeutics -- Translatable and back-translatable measurement of impulsivity and compulsivity; convergent and divergent processes -- Translational models of gambling-related decision-making -- Translational research on nicotine dependence -- The need for treatment-responsive translatable biomarkers in alcoholism research -- On the road to translation for PTSD treatment: theoretical and practical considerations of the use of human models of conditioned fear for drug development -- Translational approaches targeting reconsolidation -- Translational assessment of reward and motivational deficits in psychiatric disorders -- Affective biases in humans and animals. Robinson -- Locomotor profiling from the rodents to the clinic and back again -- Animal models of sensori-motor gating in schizophrenia: Are they still relevant? -- Attention and the cholinergic system: relevance to schizophrenia -- Attentional-set-shifting across species -- Relating Translational Neuroimaging and Amperometric Endpoints: Utility for Neuropsychiatric Drug Discovery -- Cognitive translation using the rodent touchscreen test approach -- The Paired Associates Learning (PAL) Test: 30 years of CANTAB Translational Neuroscience From Laboratory to Bedside in Dementia Research -- Translational approaches to experimental medicine.
520			_aThis book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aPharmacology.
650		0	_aPsychopharmacology.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aPsychopharmacology.
650	2	4	_aPharmacology/Toxicology.
700	1		_aRobbins, Trevor W. _eeditor.
700	1		_aSahakian, Barbara J. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319339115
830		0	_aCurrent Topics in Behavioral Neurosciences, _x1866-3370 ; _v28
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-33913-9
912			_aZDB-2-SBL
942			_cLIBRO_ELEC
999			_c227825 _d227825