000 04146nam a22005535i 4500
001 978-3-319-42059-2
003 DE-He213
005 20180206183141.0
007 cr nn 008mamaa
008 160829s2016 gw | s |||| 0|eng d
020 _a9783319420592
_9978-3-319-42059-2
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aNon-coding RNAs in Colorectal Cancer
_h[recurso electrónico] /
_cedited by Ondrej Slaby, George A. Calin.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aVIII, 252 p. 19 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v937
505 0 _aIntroduction.-Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis.-Non-coding RNAs: classification, biology and functioning.-Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer.-MicroRNAs and inflammation in colorectal cancer -- Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer -- Non-coding RNAs functioning in colorectal cancer stem cells -- MicroRNA Methylation in Colorectal Cancer -- Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer -- Part II Non-coding RNAs: new class of biomarkers in colorectal cancer -- Non-coding RNAs as biomarkers for colorectal cancer screening and early detection -- Circulating non-coding RNAs as biomarkers in colorectal cancer -- Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients -- Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics -- Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer -- Non-coding RNAs: therapeutic strategies and delivery systems -- MicroRNAs as therapeutic targets and colorectal cancer therapeutics -- Summary -- Index.
520 _aThis is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHuman genetics.
650 0 _aMolecular biology.
650 0 _aLife sciences.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
650 2 4 _aHuman Genetics.
650 2 4 _aMolecular Medicine.
650 2 4 _aLife Sciences, general.
700 1 _aSlaby, Ondrej.
_eeditor.
700 1 _aCalin, George A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319420578
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v937
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-42059-2
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c227940
_d227940