000 | 04146nam a22005535i 4500 | ||
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001 | 978-3-319-42059-2 | ||
003 | DE-He213 | ||
005 | 20180206183141.0 | ||
007 | cr nn 008mamaa | ||
008 | 160829s2016 gw | s |||| 0|eng d | ||
020 |
_a9783319420592 _9978-3-319-42059-2 |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
|
082 | 0 | 4 |
_a614.5999 _223 |
245 | 1 | 0 |
_aNon-coding RNAs in Colorectal Cancer _h[recurso electrónico] / _cedited by Ondrej Slaby, George A. Calin. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016. |
|
300 |
_aVIII, 252 p. 19 illus., 13 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v937 |
|
505 | 0 | _aIntroduction.-Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis.-Non-coding RNAs: classification, biology and functioning.-Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer.-MicroRNAs and inflammation in colorectal cancer -- Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer -- Non-coding RNAs functioning in colorectal cancer stem cells -- MicroRNA Methylation in Colorectal Cancer -- Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer -- Part II Non-coding RNAs: new class of biomarkers in colorectal cancer -- Non-coding RNAs as biomarkers for colorectal cancer screening and early detection -- Circulating non-coding RNAs as biomarkers in colorectal cancer -- Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients -- Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics -- Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer -- Non-coding RNAs: therapeutic strategies and delivery systems -- MicroRNAs as therapeutic targets and colorectal cancer therapeutics -- Summary -- Index. | |
520 | _aThis is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aMolecular biology. | |
650 | 0 | _aLife sciences. | |
650 | 0 | _aCell biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aCell Biology. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aMolecular Medicine. |
650 | 2 | 4 | _aLife Sciences, general. |
700 | 1 |
_aSlaby, Ondrej. _eeditor. |
|
700 | 1 |
_aCalin, George A. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319420578 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v937 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-42059-2 |
912 | _aZDB-2-SBL | ||
942 | _cLIBRO_ELEC | ||
999 |
_c227940 _d227940 |