000 | 03351nam a22004935i 4500 | ||
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001 | 978-3-319-42223-7 | ||
003 | DE-He213 | ||
005 | 20180206183142.0 | ||
007 | cr nn 008mamaa | ||
008 | 160830s2016 gw | s |||| 0|eng d | ||
020 |
_a9783319422237 _9978-3-319-42223-7 |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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_aMED062000 _2bisacsh |
|
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_a614.5999 _223 |
245 | 1 | 0 |
_aDefects in T Cell Trafficking and Resistance to Cancer Immunotherapy _h[recurso electrónico] / _cedited by Emmanuel Donnadieu. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016. |
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300 |
_aVIII, 199 p. 27 illus., 19 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aResistance to Targeted Anti-Cancer Therapeutics, _x2196-5501 ; _v9 |
|
505 | 0 | _aIntroduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors. | |
520 | _aThis volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aImmunology. | |
650 | 0 | _aMolecular biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aImmunology. |
650 | 2 | 4 | _aMolecular Medicine. |
700 | 1 |
_aDonnadieu, Emmanuel. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319422213 |
830 | 0 |
_aResistance to Targeted Anti-Cancer Therapeutics, _x2196-5501 ; _v9 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-42223-7 |
912 | _aZDB-2-SBL | ||
942 | _cLIBRO_ELEC | ||
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_c227954 _d227954 |