000 | 02928nam a22004935i 4500 | ||
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001 | 978-3-319-01574-3 | ||
003 | DE-He213 | ||
005 | 20180206183143.0 | ||
007 | cr nn 008mamaa | ||
008 | 160411s2016 gw | s |||| 0|eng d | ||
020 |
_a9783319015743 _9978-3-319-01574-3 |
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050 | 4 | _aRB155-155.8 | |
050 | 4 | _aQH431 | |
072 | 7 |
_aMFN _2bicssc |
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072 | 7 |
_aMED107000 _2bisacsh |
|
082 | 0 | 4 |
_a611.01816 _223 |
082 | 0 | 4 |
_a599.935 _223 |
245 | 1 | 4 |
_aThe Genetics of Type 2 Diabetes and Related Traits _h[recurso electrónico] : _bBiology, Physiology and Translation / _cedited by Jose C. Florez. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2016. |
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300 |
_aXI, 576 p. 53 illus., 13 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aPart I Genetic Discovery -- Part II Interpretation and Data Integration -- Part III From Association to Function -- Part IV Clinical Translation.. | |
520 | _aThis book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. <. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aHuman physiology. | |
650 | 0 | _aDiabetes. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aDiabetes. |
650 | 2 | 4 | _aHuman Physiology. |
700 | 1 |
_aFlorez, Jose C. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319015736 |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-01574-3 |
912 | _aZDB-2-SBL | ||
942 | _cLIBRO_ELEC | ||
999 |
_c227982 _d227982 |