000 02928nam a22004935i 4500
001 978-3-319-01574-3
003 DE-He213
005 20180206183143.0
007 cr nn 008mamaa
008 160411s2016 gw | s |||| 0|eng d
020 _a9783319015743
_9978-3-319-01574-3
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
245 1 4 _aThe Genetics of Type 2 Diabetes and Related Traits
_h[recurso electrónico] :
_bBiology, Physiology and Translation /
_cedited by Jose C. Florez.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aXI, 576 p. 53 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I Genetic Discovery -- Part II Interpretation and Data Integration -- Part III From Association to Function -- Part IV Clinical Translation..
520 _aThis book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. <.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aHuman physiology.
650 0 _aDiabetes.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aDiabetes.
650 2 4 _aHuman Physiology.
700 1 _aFlorez, Jose C.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319015736
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-01574-3
912 _aZDB-2-SBL
942 _cLIBRO_ELEC
999 _c227982
_d227982