000 | 04192nam a22006375i 4500 | ||
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001 | 978-3-030-00737-9 | ||
003 | DE-He213 | ||
005 | 20210201191253.0 | ||
007 | cr nn 008mamaa | ||
008 | 181127s2018 gw | s |||| 0|eng d | ||
020 |
_a9783030007379 _9978-3-030-00737-9 |
||
050 | 4 | _aRB155-155.8 | |
050 | 4 | _aQH431 | |
072 | 7 |
_aMFN _2bicssc |
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_aMED107000 _2bisacsh |
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_aMFN _2thema |
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082 | 0 | 4 |
_a611.01816 _223 |
082 | 0 | 4 |
_a599.935 _223 |
245 | 1 | 0 |
_aPrefoldins: the new chaperones _h[electronic resource] / _cedited by Nabil Djouder. |
250 | _a1st ed. 2018. | ||
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2018. |
|
300 |
_aIX, 135 p. 39 illus., 36 illus. in color. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1106 |
|
500 | _aAcceso multiusuario | ||
505 | 0 | _aPreface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index. | |
520 | _aThis book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world. | ||
541 |
_fUABC ; _cTemporal ; _d01/01/2021-12/31/2023. |
||
650 | 0 | _aHuman genetics. | |
650 | 0 | _aMolecular biology. | |
650 | 0 | _aCell biology. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aProteins . | |
650 | 1 | 4 |
_aHuman Genetics. _0https://scigraph.springernature.com/ontologies/product-market-codes/B12008 |
650 | 2 | 4 |
_aMolecular Medicine. _0https://scigraph.springernature.com/ontologies/product-market-codes/B1700X |
650 | 2 | 4 |
_aCell Biology. _0https://scigraph.springernature.com/ontologies/product-market-codes/L16008 |
650 | 2 | 4 |
_aCancer Research. _0https://scigraph.springernature.com/ontologies/product-market-codes/B11001 |
650 | 2 | 4 |
_aProtein Science. _0https://scigraph.springernature.com/ontologies/product-market-codes/L14040 |
650 | 2 | 4 |
_aProtein Structure. _0https://scigraph.springernature.com/ontologies/product-market-codes/L14050 |
700 | 1 |
_aDjouder, Nabil. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer Nature eBook | |
776 | 0 | 8 |
_iPrinted edition: _z9783030007362 |
776 | 0 | 8 |
_iPrinted edition: _z9783030007386 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1106 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-030-00737-9 |
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