000 04192nam a22006375i 4500
001 978-3-030-00737-9
003 DE-He213
005 20210201191253.0
007 cr nn 008mamaa
008 181127s2018 gw | s |||| 0|eng d
020 _a9783030007379
_9978-3-030-00737-9
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aMFN
_2thema
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
245 1 0 _aPrefoldins: the new chaperones
_h[electronic resource] /
_cedited by Nabil Djouder.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aIX, 135 p. 39 illus., 36 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1106
500 _aAcceso multiusuario
505 0 _aPreface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index.
520 _aThis book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aHuman genetics.
650 0 _aMolecular biology.
650 0 _aCell biology.
650 0 _aCancer research.
650 0 _aProteins .
650 1 4 _aHuman Genetics.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B12008
650 2 4 _aMolecular Medicine.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
650 2 4 _aCell Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L16008
650 2 4 _aCancer Research.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B11001
650 2 4 _aProtein Science.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14040
650 2 4 _aProtein Structure.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14050
700 1 _aDjouder, Nabil.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783030007362
776 0 8 _iPrinted edition:
_z9783030007386
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1106
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-030-00737-9
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c241509
_d241508