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082 0 4 _a579.135
_223
245 1 0 _aMolecular Mechanisms of Microbial Evolution
_h[electronic resource] /
_cedited by Pabulo H. Rampelotto.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXIII, 448 p. 71 illus., 54 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aGrand Challenges in Biology and Biotechnology,
_x2367-1017
500 _aAcceso multiusuario
520 _aOne of the most profound paradigms that have transformed our understanding about life over the last decades was the acknowledgement that microorganisms play a central role in shaping the past and present environments on Earth and the nature of all life forms. Each organism is the product of its history and all extant life traces back to common ancestors, which were microorganisms. Nowadays, microorganisms represent the vast majority of biodiversity on Earth and have survived nearly 4 billion years of evolutionary change. Microbial evolution occurred and continues to take place in a great variety of environmental conditions. However, we still know little about the processes of evolution as applied to microorganisms and microbial populations. In addition, the molecular mechanisms by which microorganisms communicate/interact with each other and with multicellular organisms remains poorly understood. Such patterns of microbe-host interaction are essential to understand the evolution of microbial symbiosis and pathogenesis. Recent advances in DNA sequencing, high-throughput technologies, and genetic manipulation systems have enabled studies that directly characterize the molecular and genomic bases of evolution, producing data that are making us change our view of the microbial world. The notion that mutations in the coding regions of genomes are, in combination with selective forces, the main contributors to biodiversity needs to be re-examined as evidence accumulates, indicating that many non-coding regions that contain regulatory signals show a high rate of variation even among closely related organisms. Comparative analyses of an increasing number of closely related microbial genomes have yielded exciting insight into the sources of microbial genome variability with respect to gene content, gene order and evolution of genes with unknown functions. Furthermore, laboratory studies (i.e. experimental microbial evolution) are providing fundamental biological insight through direct observation of the evolution process. They not only enable testing evolutionary theory and principles, but also have applications to metabolic engineering and human health. Overall, these studies ranging from viruses to Bacteria to microbial Eukaryotes are illuminating the mechanisms of evolution at a resolution that Darwin, Delbruck and Dobzhansky could barely have imagined. Consequently, it is timely to review and highlight the progress so far as well as discuss what remains unknown and requires future research. This book explores the current state of knowledge on the molecular mechanisms of microbial evolution with a collection of papers written by authors who are leading experts in the field.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aMicrobial genetics.
650 0 _aMicrobial genomics.
650 0 _aEvolutionary biology.
650 0 _aMicrobiology.
650 1 4 _aMicrobial Genetics and Genomics.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L32010
650 2 4 _aEvolutionary Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L21001
650 2 4 _aApplied Microbiology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/C12010
700 1 _aRampelotto, Pabulo H.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319690773
776 0 8 _iPrinted edition:
_z9783319690797
776 0 8 _iPrinted edition:
_z9783030098674
830 0 _aGrand Challenges in Biology and Biotechnology,
_x2367-1017
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-69078-0
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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