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_9978-981-13-1286-1
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
245 1 0 _aNeural Regulation of Metabolism
_h[electronic resource] /
_cedited by Qi Wu, Ruimao Zheng.
250 _a1st ed. 2018.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2018.
300 _aXI, 233 p. 30 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1090
500 _aAcceso multiusuario
505 0 _aFunctional interrogation of the AgRP neural circuits in control of appetite, body weight, and behaviors -- The Leptin Signalings -- The Leptin Resistance -- Neuronal cAMP/PKA Signaling and Energy Homeostasis -- POMC neurons feeding and reward -- Synaptic Regulation of Metabolism -- Glial Regulation of Energy Metabolism -- Regulation of Lipolysis in Adipose Tissue and Clinical Significance -- Electrophysiological mechanism of peripheral hormones and nutrients regulating energy homeostasis -- Central Circadian Clock Regulates Energy Metabolism -- Ghrelin signaling in immunometabolism and inflamm-aging -- Current genetic techniques in neural circuit control of feeding and energy metabolism.
520 _aThis book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aNeurosciences.
650 0 _aHuman physiology.
650 0 _aCell biology.
650 0 _aBiochemistry.
650 1 4 _aNeurosciences.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B18006
650 2 4 _aHuman Physiology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B13004
650 2 4 _aCell Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L16008
650 2 4 _aBiochemistry, general.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14005
700 1 _aWu, Qi.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aZheng, Ruimao.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811312854
776 0 8 _iPrinted edition:
_z9789811312878
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1090
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-13-1286-1
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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