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020 _a9789811084881
_9978-981-10-8488-1
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
245 1 0 _aNicotinic Acetylcholine Receptor Signaling in Neuroprotection
_h[electronic resource] /
_cedited by Akinori Akaike, Shun Shimohama, Yoshimi Misu.
250 _a1st ed. 2018.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2018.
300 _aX, 191 p. 62 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aAcceso multiusuario
505 0 _a1.Overview -- 2.In vivo imaging of nicotinic acetylcholine receptors in the central nervous system -- 3.A new aspect of cholinergic transmission in the central nervous system -- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection -- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection -- 6.Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans -- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders -- 8.Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer's and Parkinson's diseases -- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors -- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer's disease: the influence of smoking and nicotine.
506 0 _aOpen Access
520 _aThis open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This book is published with open access under a CC BY 4.0 license.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aNeurosciences.
650 0 _aNeurology .
650 0 _aPharmacology.
650 1 4 _aNeurosciences.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B18006
650 2 4 _aNeurology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H36001
650 2 4 _aPharmacology/Toxicology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B21007
700 1 _aAkaike, Akinori.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aShimohama, Shun.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMisu, Yoshimi.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811084874
776 0 8 _iPrinted edition:
_z9789811084898
776 0 8 _iPrinted edition:
_z9789811341663
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-10-8488-1
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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942 _cLIBRO_ELEC
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