000 05024nam a22005655i 4500
001 978-3-319-95390-8
003 DE-He213
005 20210201191321.0
007 cr nn 008mamaa
008 181024s2018 gw | s |||| 0|eng d
020 _a9783319953908
_9978-3-319-95390-8
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aSelenium
_h[electronic resource] /
_cedited by Bernhard Michalke.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXV, 522 p. 57 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular and Integrative Toxicology,
_x2168-4219
500 _aAcceso multiusuario
505 0 _aPart I - Overview: 1. Selenium in Human Health and Disease: an Overview -- Part II - Bioaccessibility and Dietary Aspects of Selenium: 2. Selenium in Soils and Crops -- 3. Dietary Aspects for Selenium and/or Selenium Compounds -- Part III - Genes, Proteins, Pathways, and Metabolism Related to Selenium: 4. Contribution of the Yeast Saccharomyces Cerevisiae Model to Understand the Mechanisms of Selenium Toxicity -- 5. Selenium Metabolism, Regulation And Sex Differences In Mammals -- Part IV - The Role of Selenium within Redox System, Inflammation, and Thyroid Interaction: 6. Oxidative Stress, Selenium Redox Systems Including GPX / TXNRD Families -- 7. Selenium and Inflammatory Mediators -- 8. Selenium and Thyroid Function -- Part V - The Role of Selenium in Neurodevelopment and Neurological Disorders: 9. Selenium and Neurodevelopment -- 10. Selenium and Autism Spectrum Disorder -- 11. Selenium in Ischemic Stroke -- 12. Selenium neurotoxicity and Amyotrophic Lateral Sclerosis: An Epidemiologic Perspective -- Part VI - The Role of Selenium in Cancer: 13. Therapeutic Potential of Selenium Compounds in the Treatment of Cancer -- 14. Selenocystine and Cancer -- 15. Selenium in Radiation Oncology -- Part VII - The Role of Selenium in Various Diseases and Health Issues: 16. Selenium and Cardiovascular Disease: Epidemiological Evidence of a Possible U-Shaped Relationship -- 17. Selenium and Diabetes -- 18. Uncovering the Importance of Selenium in Muscle Disease -- 19. Selenium in Immune Response and Intensive Care -- 20. Selenium and Toxicological Aspects: Cytotoxicity, Cellular Bioavailability and Biotransformation of Se-Species -- 21. Selenium Nanoparticles - Biomedical Application -- 22. Selenium Interactions with Other Trace Elements, with Nutrients (and Drugs) in Humans -- Part VIII - Selenium Analytics, Speciation and Biomonitoring: 23. Biomarkers of Selenium Status -- 24. Human Biomonitoring of Selenium Exposure -- 25. Bioanalytical Chemistry of Selenium.
520 _aThis book summarizes the fast-growing and current knowledge about selenium interaction with cancer, diabetes, neuro-degeneration, heart disease, muscle disorders, HIV and several more. A special focus will be placed on in-depth knowledge about gene expression, selenoprotein biosynthesis, seleno-metabolism--as well as the molecular pathways, physiological roles, and the molecular action of selenium including interaction with other elements and vitamins or as Se-nanoparticles. The reader will receive the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases as well as about cellular bioavailability and cytotoxicity, de-balanced immune response, inflammation or dietary aspects.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aPharmacology.
650 0 _aMedical biochemistry.
650 0 _aMolecular biology.
650 1 4 _aPharmacology/Toxicology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B21007
650 2 4 _aMedical Biochemistry.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H35005
650 2 4 _aMolecular Medicine.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
700 1 _aMichalke, Bernhard.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319953892
776 0 8 _iPrinted edition:
_z9783319953915
776 0 8 _iPrinted edition:
_z9783030070267
830 0 _aMolecular and Integrative Toxicology,
_x2168-4219
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-95390-8
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c242077
_d242076