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020 _a9789811304842
_9978-981-13-0484-2
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072 7 _aMMFM
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072 7 _aMED052000
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072 7 _aMKFM
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082 0 4 _a616.9101
_223
245 1 0 _aHIV Vaccines and Cure
_h[electronic resource] :
_bThe Path Towards Finding an Effective Cure and Vaccine /
_cedited by Linqi Zhang, Sharon R. Lewin.
250 _a1st ed. 2018.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2018.
300 _aXV, 318 p. 21 illus., 16 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1075
500 _aAcceso multiusuario
505 0 _aHIV Vaccine Efficacy Trials: RV144 and beyond -- HIV T-cell vaccines -- HIV broadly neutralizing antibodies: VRC01 and beyond -- Structural features of broadly neutralizing antibodies and rational design of vaccine -- Monkey models and HIV vaccine research -- Treatment of HIV for the Prevention of Transmission in Discordant Couples and at the Population Level -- HIV persistence on antiretroviral therapy and barriers to a cure -- The molecular biology of HIV latency -- Cellular determinants of HIV persistence on antiretroviral therapy -- In Vitro and In Vivo Models of HIV Latency -- Measuring HIV persistence on antiretroviral therapy -- Clinical interventions in HIV cure research.
520 _aThis book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aVirology.
650 0 _aVaccines.
650 0 _aImmunology.
650 0 _aAnimal models in research.
650 1 4 _aVirology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B22003
650 2 4 _aVaccine.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B16010
650 2 4 _aImmunology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B14000
650 2 4 _aAnimal Models.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L25050
700 1 _aZhang, Linqi.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aLewin, Sharon R.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811304835
776 0 8 _iPrinted edition:
_z9789811304859
776 0 8 _iPrinted edition:
_z9789811344282
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1075
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-13-0484-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
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