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020 _a9789811314865
_9978-981-13-1486-5
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072 7 _aMED062000
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072 7 _aMJCL
_2thema
082 0 4 _a614.5999
_223
245 1 0 _aRole of Tyrosine Kinases in Gastrointestinal Malignancies
_h[electronic resource] /
_cedited by Ganji Purnachandra Nagaraju.
250 _a1st ed. 2018.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2018.
300 _aXV, 241 p. 28 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aAcceso multiusuario
505 0 _aChapter 1. 1. Overview of tyrosine kinases and their receptors in gastrointestinal malignancies- -- Chapter 2. EGFR and Erb-B2R (HER2): their role in Esophagus cancer -- Chapter 3. HGFR and FGFR2: their role in progression and metastasis of Esophagus cancer -- Chapter 4. Role of Src and VEGF R tyrosine kinases in Esophagus cancer -- Chapter 5. HGF receptor tyrosine kinase in gastric cancer. - Chapter 6. The EGF/ErbB receptor family of tyrosine kinases in gastric cancer -- Chapter 7. Helicobacter pylori CagA protein: its role and interaction tyrosine kinases in gastric cancer -- Chapter 8. RON receptor tyrosine kinase in pancreatic cancer progression -- Chapter 9. EGFR and Cytoplasmic kinases Src targeting in pancreatic cancer -- Chapter 10. VEGF and PDGFR targeting in pancreatic cancer -- Chapter 11. c-KIT, and FLT-3: their role in Hepatocellular carcinoma -- Chapter 12. VEGFR, and PDGFR: their targeting in Liver Cancer -- Chapter 13. EGFR and FGFR in growth and metastasis of colorectal cancer -- Chapter 14. VEGFR, and PDGFR: their targeting in colorectal cancerm -- Chapter 15. Nano materials and their impact on tyrosine kinase on selected gastrointestinal malignancies -- Chapter 16. Tyrosine kinase inhibitors and their clinical prospective in gastrointestinal malignancies -- Chapter 17. Drug resistance against tyrosine kinase inhibitors in gastrointestinal malignancies -- Chapter 18. Tyrosine kinases: their expression, diagnostic, therapeutic and prognostic aspects in gastrointestinal cancers.
520 _aThe aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aCancer research.
650 0 _aHuman physiology.
650 0 _aCell biology.
650 0 _aProteins .
650 0 _aGene expression.
650 0 _aOncology  .
650 1 4 _aCancer Research.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B11001
650 2 4 _aHuman Physiology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B13004
650 2 4 _aCell Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L16008
650 2 4 _aReceptors.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14110
650 2 4 _aGene Expression.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B12010
650 2 4 _aOncology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H33160
700 1 _aNagaraju, Ganji Purnachandra.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811314858
776 0 8 _iPrinted edition:
_z9789811314872
776 0 8 _iPrinted edition:
_z9789811346408
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-13-1486-5
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