000 | 04849nam a22005655i 4500 | ||
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001 | 978-981-13-2158-0 | ||
003 | DE-He213 | ||
005 | 20210201191348.0 | ||
007 | cr nn 008mamaa | ||
008 | 181127s2018 si | s |||| 0|eng d | ||
020 |
_a9789811321580 _9978-981-13-2158-0 |
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050 | 4 | _aQH345 | |
050 | 4 | _aQD415-436 | |
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_aPSB _2bicssc |
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_aSCI007000 _2bisacsh |
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_aPSB _2thema |
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082 | 0 | 4 |
_a572 _223 |
245 | 1 | 0 |
_aGlycobiophysics _h[electronic resource] / _cedited by Yoshiki Yamaguchi, Koichi Kato. |
250 | _a1st ed. 2018. | ||
264 | 1 |
_aSingapore : _bSpringer Singapore : _bImprint: Springer, _c2018. |
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300 |
_aXIII, 277 p. 110 illus., 74 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_atext file _bPDF _2rda |
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490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1104 |
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500 | _aAcceso multiusuario | ||
505 | 0 | _aPreface -- Chapter 1: The effect of N-glycans on glycoprotein folding and protein dynamics -- Chapter 2: Synthesis of glycosylated metal complexes for probing carbohydrate-carbohydrate interactions -- Chapter 3: Unraveling of lipid raft organization in cell plasma membranes by single-molecule imaging of ganglioside probes -- Chapter 4: MALDI mass spectrometry imaging of N-linked glycans in tissues -- Chapter 5: Modern-omics technologies for isobaric glycan and glycoconjugate structure determination -- Chapter 6: Synchrotron-radiation vacuum-ultraviolet circular-dichroism spectroscopy for characterizing the structure of saccharides -- Chapter 7: Biophysical analyses for probing glycan-protein interactions -- Chapter 8: Structural aspects of ER glycoprotein quality-control system mediated by glucose tagging -- Chapter 9: Structural basis of protein Asn-glycosylation by oligosaccharyltransferases -- Chapter 10: Visualization of functional structure and kinetic dynamics of cellulases -- Chapter 11: Structure and dynamics of immunoglobulin G glycoproteins -- Chapter 12: Biophysical Approaches to Solve the Structures of the Complex Glycan Shield of Chloroviruses -- Chapter 13: Quantifying weak glycan-protein interactions using a Biolayer Interferometry competition assay: Applications to ECL lectin and X-31 influenza hemagglutinin. | |
520 | _aThis book presents state of the art biophysical approaches to issues in glycobiology that have cutting-edge applications. Despite the importance of glycosylation, the complexity, heterogeneity, and flexibility of the glycans have inhibited their study. Each chapter in this book explains very recent significant advances in biophysical approaches through the use of techniques such as NMR spectroscopy, mass spectrometry, single-molecule imaging, X-ray crystallography, high-speed atomic force microscopy, and computational simulation and their integrative application. Concrete examples are provided of the value of these techniques in addressing key problems in the field. In addition, significant functional glycobiological issues are considered. For example, glycolipids can form dynamic clusters on cell membranes and provide platforms for molecules involved in cell recognition and subsequent signal transduction. The detailed delineation of these molecular systems is discussed, revealing their structural complexity and ability to assemble transiently. This timely book will be of value for graduate students and postdocs interested in frontier topics in glycoscience and also for senior bio-researchers in academic and industrial fields. | ||
541 |
_fUABC ; _cTemporal ; _d01/01/2021-12/31/2023. |
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650 | 0 | _aBiochemistry. | |
650 | 0 | _aBiophysics. | |
650 | 0 | _aBiological physics. | |
650 | 1 | 4 |
_aBiochemistry, general. _0https://scigraph.springernature.com/ontologies/product-market-codes/L14005 |
650 | 2 | 4 |
_aBiological and Medical Physics, Biophysics. _0https://scigraph.springernature.com/ontologies/product-market-codes/P27008 |
700 | 1 |
_aYamaguchi, Yoshiki. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
|
700 | 1 |
_aKato, Koichi. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer Nature eBook | |
776 | 0 | 8 |
_iPrinted edition: _z9789811321573 |
776 | 0 | 8 |
_iPrinted edition: _z9789811321597 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1104 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-13-2158-0 |
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