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001 978-3-319-91116-8
003 DE-He213
005 20210201191348.0
007 cr nn 008mamaa
008 190201s2018 gw | s |||| 0|eng d
020 _a9783319911168
_9978-3-319-91116-8
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
100 1 _aBennett, Maxwell.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aStress, Trauma and Synaptic Plasticity
_h[electronic resource] /
_cby Maxwell Bennett, Jim Lagopoulos.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXXXIII, 231 p. 47 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aAcceso multiusuario
505 0 _aGrey matter changes in the brain following stress and trauma -- Synaptic changes responsible for grey matter changes in the brain of animal models following stress -- Identification of the core neural network subserving PTSD in animal models and their modulation -- Modulation of the core neural network in stress: the role of Brain Derived Neurotrophic Factor & LTP -- Modulation of the core neural network in stress: the role of Endocannabinoids & LTD -- Functioning of the core neural network in fear and extinction -- Modulation of the core synaptic network in extinction: the role of Brain Derived Neurotrophic Factor -- Appendix 1: F-actin determination of dendritic spine integrity -- Appendix 2: Regulation of NMDA receptors. .
520 _aThis book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma. The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book's initial sections, the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These connections are chiefly modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor-mediated plasticity of these synapses is discussed, with particular attention paid to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse's physical stability. The book concludes by integrating the observations made in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that promote fear and extinction. Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aNeurosciences.
650 0 _aNeurobiology.
650 0 _aNeurology .
650 1 4 _aNeurosciences.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B18006
650 2 4 _aNeurobiology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L25066
650 2 4 _aNeurology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H36001
700 1 _aLagopoulos, Jim.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319911151
776 0 8 _iPrinted edition:
_z9783319911175
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-91116-8
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c242593
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