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082 0 4 _a570.285
_223
100 1 _aMrozek, Dariusz.
_eauthor.
_0(orcid)0000-0001-6764-6656
_1https://orcid.org/0000-0001-6764-6656
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aScalable Big Data Analytics for Protein Bioinformatics
_h[electronic resource] :
_bEfficient Computational Solutions for Protein Structures /
_cby Dariusz Mrozek.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXXVI, 315 p. 151 illus., 110 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aComputational Biology,
_x1568-2684 ;
_v28
500 _aAcceso multiusuario
505 0 _aFormal Model of 3D Protein Structures for Functional Genomics, Comparative Bioinformatics, and Molecular Modeling -- Multithreaded PSS-SQL for Searching Databases of Secondary Structures -- GPU and CUDA for 3D Protein Structure Similarity Searching -- Cloud Computing for 3D Protein Structure Alignment -- General Discussion and Concluding Remarks.
520 _aThis book presents a focus on proteins and their structures. The text describes various scalable solutions for protein structure similarity searching, carried out at main representation levels and for prediction of 3D structures of proteins. Emphasis is placed on techniques that can be used to accelerate similarity searches and protein structure modeling processes. The content of the book is divided into four parts. The first part provides background information on proteins and their representation levels, including a formal model of a 3D protein structure used in computational processes, and a brief overview of the technologies used in the solutions presented in the book. The second part of the book discusses Cloud services that are utilized in the development of scalable and reliable cloud applications for 3D protein structure similarity searching and protein structure prediction. The third part of the book shows the utilization of scalable Big Data computational frameworks, like Hadoop and Spark, in massive 3D protein structure alignments and identification of intrinsically disordered regions in protein structures. The fourth part of the book focuses on finding 3D protein structure similarities, accelerated with the use of GPUs and the use of multithreading and relational databases for efficient approximate searching on protein secondary structures. The book introduces advanced techniques and computational architectures that benefit from recent achievements in the field of computing and parallelism. Recent developments in computer science have allowed algorithms previously considered too time-consuming to now be efficiently used for applications in bioinformatics and the life sciences. Given its depth of coverage, the book will be of interest to researchers and software developers working in the fields of structural bioinformatics and biomedical databases.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aBioinformatics.
650 0 _aComputer communication systems.
650 0 _aProteins .
650 0 _aBiomathematics.
650 1 4 _aComputational Biology/Bioinformatics.
_0https://scigraph.springernature.com/ontologies/product-market-codes/I23050
650 2 4 _aComputer Communication Networks.
_0https://scigraph.springernature.com/ontologies/product-market-codes/I13022
650 2 4 _aProtein Structure.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14050
650 2 4 _aBioinformatics.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L15001
650 2 4 _aMathematical and Computational Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/M31000
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319988382
776 0 8 _iPrinted edition:
_z9783319988405
776 0 8 _iPrinted edition:
_z9783030075385
830 0 _aComputational Biology,
_x1568-2684 ;
_v28
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-98839-9
912 _aZDB-2-SCS
912 _aZDB-2-SXCS
942 _cLIBRO_ELEC
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