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020 _a9783319741864
_9978-3-319-74186-4
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_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a616.9041
_223
245 1 0 _aDrug Resistance in Leishmania Parasites
_h[electronic resource] :
_bConsequences, Molecular Mechanisms and Possible Treatments /
_cedited by Alicia Ponte-Sucre, Maritza Padrón-Nieves.
250 _a2nd ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXVII, 376 p. 24 illus., 14 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aAcceso multiusuario
505 0 _aPrologue -- Introduction -- Part I Determinant features in Leishmaniasis -- Molecular evolution and phylogeny of Leishmania -- The role of reservoirs: canine Leishmaniasis -- Epidemiology of Leishmaniasis in the time of drug resistance -- The role of the immune system in resistance to infection -- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance -- Co-infection with HIV -- Visceral Leishmaniasis -- Tegumentary Leishmaniasis -- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis -- Part III Molecular featrues of drug resistant Leishmania -- Genetic Expression and drug resistance, the role of proteomics -- The role of AMC transporters in drug-resistant Leishmania -- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance -- Part IV Pharmacology and chemotherapy of Leishmaniasis -- Classical vs. novel treatment regimens -- Bioinformatics in Leishmania drug design -- Leishmanis mitochondria, a druggable organelle -- P-glycoprotein-like transporters in Leishmania: a search for reversal agents -- Part V Strategies to circumvent drug resistance in Leishmania -- The relevance of susceptibility tests, breakpoints and markers -- The concept of fitness in Leishmania.
520 _aDrug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aDrug resistance.
650 0 _aInfectious diseases.
650 0 _aPharmaceutical technology.
650 0 _aVaccines.
650 0 _aParasitology.
650 0 _aMicrobiology.
650 1 4 _aDrug Resistance.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B16020
650 2 4 _aInfectious Diseases.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H33096
650 2 4 _aPharmaceutical Sciences/Technology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B21010
650 2 4 _aVaccine.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B16010
650 2 4 _aParasitology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B19002
650 2 4 _aMicrobiology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L23004
700 1 _aPonte-Sucre, Alicia.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aPadrón-Nieves, Maritza.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319741857
776 0 8 _iPrinted edition:
_z9783319741871
776 0 8 _iPrinted edition:
_z9783030089306
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-74186-4
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c242841
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