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020 _a9789811073472
_9978-981-10-7347-2
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
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072 7 _aMED107000
_2bisacsh
072 7 _aMFN
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082 0 4 _a611.01816
_223
100 1 _aKangueane, Pandjassarame.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aProtein-Protein and Domain-Domain Interactions
_h[electronic resource] /
_cby Pandjassarame Kangueane, Christina Nilofer.
250 _a1st ed. 2018.
264 1 _aSingapore :
_bSpringer Singapore :
_bImprint: Springer,
_c2018.
300 _aXIX, 207 p. 161 illus., 82 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aAcceso multiusuario
505 0 _aModule 1. Preface -- Module 2. Introduction to protein complexes -- Module 3. Historical advancement -- Module 4. Databases for protein complexes -- Module 5. Types of protein complexes -- Module 6. Hetero dimer protein complexes -- Module 7. Homo dimer protein complexes -- Module 8. Multimer protein complexes -- Module 9. Interfaces in protein complexes -- Module 10. Principles of protein-protein binding -- Module 11. Homodimer folding and binding -- Module 12. Gene fusion and protein complexes -- Module 13. Domain-domain interactions -- Module 14. Protein docking: Methods, software tools and servers -- Module 15. Protein complexes, pathways and networks -- Module 16. Protein complexes and biological functions -- Module 17. Protein complexes in diseases -- Module 18. Protein complexes in drug discovery & vaccine development -- Module 19. Protein complexes in genome and proteome analysis -- Module 20. Conclusions & challenges.
520 _aThis book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aMedical genetics.
650 0 _aBioinformatics.
650 0 _aProteins .
650 0 _aVaccines.
650 1 4 _aGene Function.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B12030
650 2 4 _aComputational Biology/Bioinformatics.
_0https://scigraph.springernature.com/ontologies/product-market-codes/I23050
650 2 4 _aProtein Science.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L14040
650 2 4 _aVaccine.
_0https://scigraph.springernature.com/ontologies/product-market-codes/B16010
700 1 _aNilofer, Christina.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811073465
776 0 8 _iPrinted edition:
_z9789811073489
776 0 8 _iPrinted edition:
_z9789811339424
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-10-7347-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c243914
_d243913