000 | 04493nam a22005895i 4500 | ||
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001 | 978-981-10-7347-2 | ||
003 | DE-He213 | ||
005 | 20210201191457.0 | ||
007 | cr nn 008mamaa | ||
008 | 180216s2018 si | s |||| 0|eng d | ||
020 |
_a9789811073472 _9978-981-10-7347-2 |
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050 | 4 | _aRB155-155.8 | |
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_aMFN _2bicssc |
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_aMFN _2thema |
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_a611.01816 _223 |
100 | 1 |
_aKangueane, Pandjassarame. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut |
|
245 | 1 | 0 |
_aProtein-Protein and Domain-Domain Interactions _h[electronic resource] / _cby Pandjassarame Kangueane, Christina Nilofer. |
250 | _a1st ed. 2018. | ||
264 | 1 |
_aSingapore : _bSpringer Singapore : _bImprint: Springer, _c2018. |
|
300 |
_aXIX, 207 p. 161 illus., 82 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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500 | _aAcceso multiusuario | ||
505 | 0 | _aModule 1. Preface -- Module 2. Introduction to protein complexes -- Module 3. Historical advancement -- Module 4. Databases for protein complexes -- Module 5. Types of protein complexes -- Module 6. Hetero dimer protein complexes -- Module 7. Homo dimer protein complexes -- Module 8. Multimer protein complexes -- Module 9. Interfaces in protein complexes -- Module 10. Principles of protein-protein binding -- Module 11. Homodimer folding and binding -- Module 12. Gene fusion and protein complexes -- Module 13. Domain-domain interactions -- Module 14. Protein docking: Methods, software tools and servers -- Module 15. Protein complexes, pathways and networks -- Module 16. Protein complexes and biological functions -- Module 17. Protein complexes in diseases -- Module 18. Protein complexes in drug discovery & vaccine development -- Module 19. Protein complexes in genome and proteome analysis -- Module 20. Conclusions & challenges. | |
520 | _aThis book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins. | ||
541 |
_fUABC ; _cTemporal ; _d01/01/2021-12/31/2023. |
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650 | 0 | _aMedical genetics. | |
650 | 0 | _aBioinformatics. | |
650 | 0 | _aProteins . | |
650 | 0 | _aVaccines. | |
650 | 1 | 4 |
_aGene Function. _0https://scigraph.springernature.com/ontologies/product-market-codes/B12030 |
650 | 2 | 4 |
_aComputational Biology/Bioinformatics. _0https://scigraph.springernature.com/ontologies/product-market-codes/I23050 |
650 | 2 | 4 |
_aProtein Science. _0https://scigraph.springernature.com/ontologies/product-market-codes/L14040 |
650 | 2 | 4 |
_aVaccine. _0https://scigraph.springernature.com/ontologies/product-market-codes/B16010 |
700 | 1 |
_aNilofer, Christina. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer Nature eBook | |
776 | 0 | 8 |
_iPrinted edition: _z9789811073465 |
776 | 0 | 8 |
_iPrinted edition: _z9789811073489 |
776 | 0 | 8 |
_iPrinted edition: _z9789811339424 |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-10-7347-2 |
912 | _aZDB-2-SBL | ||
912 | _aZDB-2-SXB | ||
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999 |
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