000 04468nam a22005895i 4500
001 978-3-319-72041-8
003 DE-He213
005 20210201191458.0
007 cr nn 008mamaa
008 180216s2018 gw | s |||| 0|eng d
020 _a9783319720418
_9978-3-319-72041-8
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aPSF
_2thema
082 0 4 _a571.6
_223
245 1 0 _aCellular and Molecular Toxicology of Nanoparticles
_h[electronic resource] /
_cedited by Quaiser Saquib, Mohammad Faisal, Abdulaziz A. Al-Khedhairy, Abdulrahman A. Alatar.
250 _a1st ed. 2018.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXVI, 346 p. 85 illus., 74 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1048
500 _aAcceso multiusuario
520 _aThis edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called "biomolecular corona". The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.
541 _fUABC ;
_cTemporal ;
_d01/01/2021-12/31/2023.
650 0 _aCell biology.
650 0 _aNanotechnology.
650 0 _aBiology-Technique.
650 1 4 _aCell Biology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L16008
650 2 4 _aNanotechnology.
_0https://scigraph.springernature.com/ontologies/product-market-codes/Z14000
650 2 4 _aBiological Techniques.
_0https://scigraph.springernature.com/ontologies/product-market-codes/L28000
700 1 _aSaquib, Quaiser.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aFaisal, Mohammad.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aAl-Khedhairy, Abdulaziz A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aAlatar, Abdulrahman A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319720401
776 0 8 _iPrinted edition:
_z9783319720425
776 0 8 _iPrinted edition:
_z9783030101503
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v1048
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-72041-8
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c243934
_d243933