000 04782nam a22005775i 4500
001 978-3-031-23781-2
003 DE-He213
005 20240207153541.0
007 cr nn 008mamaa
008 230310s2023 sz | s |||| 0|eng d
020 _a9783031237812
_9978-3-031-23781-2
050 4 _aQH623
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aPSF
_2thema
082 0 4 _a571.6
_223
245 1 0 _aIntegrins in Health and Disease
_h[electronic resource] :
_bKey Effectors of Cell-Matrix and Cell-Cell Interactions /
_cedited by Donald Gullberg, Johannes A. Eble.
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aXII, 472 p. 1 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiology of Extracellular Matrix,
_x2191-1959 ;
_v13
500 _aAcceso multiusuario
505 0 _aPart 1: Knockouts and animal models -- Integrins α1β1 and α2β1 - The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens.
520 _aIntegrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find "Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions" authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
541 _fUABC ;
_cPerpetuidad
650 0 _aCell adhesion.
650 0 _aCytology.
650 0 _aProteins .
650 1 4 _aCell Adhesion.
650 2 4 _aCell Biology.
650 2 4 _aProtein Biochemistry.
700 1 _aGullberg, Donald.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aEble, Johannes A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031237805
776 0 8 _iPrinted edition:
_z9783031237829
776 0 8 _iPrinted edition:
_z9783031237836
830 0 _aBiology of Extracellular Matrix,
_x2191-1959 ;
_v13
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-23781-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c261274
_d261273