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245 1 0 _aVoltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease
_h[electronic resource] /
_cedited by Jörg Striessnig.
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aXII, 316 p. 100 illus., 30 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x1865-0325 ;
_v279
500 _aAcceso multiusuario
505 0 _aPreface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation-Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
520 _aThe aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
541 _fUABC ;
_cPerpetuidad
650 0 _aPharmacology.
650 0 _aMedical genetics.
650 0 _aHuman physiology.
650 1 4 _aPharmacology.
650 2 4 _aMedical Genetics.
650 2 4 _aHuman Physiology.
700 1 _aStriessnig, Jörg.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031384363
776 0 8 _iPrinted edition:
_z9783031384387
776 0 8 _iPrinted edition:
_z9783031384394
830 0 _aHandbook of Experimental Pharmacology,
_x1865-0325 ;
_v279
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-38437-0
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
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