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_aVoltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease _h[electronic resource] / _cedited by Jörg Striessnig. |
250 | _a1st ed. 2023. | ||
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2023. |
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300 |
_aXII, 316 p. 100 illus., 30 illus. in color. _bonline resource. |
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_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_atext file _bPDF _2rda |
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490 | 1 |
_aHandbook of Experimental Pharmacology, _x1865-0325 ; _v279 |
|
500 | _aAcceso multiusuario | ||
505 | 0 | _aPreface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation-Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits. | |
520 | _aThe aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation. | ||
541 |
_fUABC ; _cPerpetuidad |
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650 | 0 | _aPharmacology. | |
650 | 0 | _aMedical genetics. | |
650 | 0 | _aHuman physiology. | |
650 | 1 | 4 | _aPharmacology. |
650 | 2 | 4 | _aMedical Genetics. |
650 | 2 | 4 | _aHuman Physiology. |
700 | 1 |
_aStriessnig, Jörg. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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_iPrinted edition: _z9783031384394 |
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_aHandbook of Experimental Pharmacology, _x1865-0325 ; _v279 |
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_zLibro electrónico _uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-38437-0 |
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