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020 _a9783031297502
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050 4 _aQH315-320
072 7 _aMBGR
_2bicssc
072 7 _aMED062000
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072 7 _aMBGR
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082 0 4 _a610.72
_223
245 1 0 _aBiological and Clinical Landscape of Meningiomas
_h[electronic resource] /
_cedited by Gelareh Zadeh, Roland Goldbrunner, Boris Krischek, Farshad Nassiri.
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aXVII, 255 p. 55 illus., 33 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1416
500 _aAcceso multiusuario
505 0 _aChapter 1. Introduction and History of Meningiomas -- Chapter 2. Clinical Presentation and Prognosis -- Chapter 3. Imaging Characteristics of Meningiomas -- Chapter 4. Histopathology of Meningiomas -- Chapter 5. Skull Base Meningiomas -- Chapter 6. Spinal Meningiomas -- Chapter 7. Surgical Therapies -- Chapter 8. Radiation Therapies -- Chapter 9. Illustrative Cases -- Chapter 10. Advances in CNS Tumor Classification -- Chapter 11. Genomic Landscape -- Chapter 12. Radiation-Induced Meningiomas -- Chapter 13. Meningioma Predisposing Syndromes -- Chapter 14. Epigentic Landscape -- Chapter 15. Immune Profile -- Chapter 16. PDX Models/Mouse Models/Cell Lines -- Chapter 17. Novel Medical Therapies -- Chapter 18. Quality of Life in Menigioma Patients -- Chapter 19. Illustrative Cases: Revisited with Adjuvant Molecular Data -- Chapter 20. Future Directions in Management.
520 _a"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike.".
541 _fUABC ;
_cPerpetuidad
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 1 4 _aBiomedical Research.
700 1 _aZadeh, Gelareh.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGoldbrunner, Roland.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKrischek, Boris.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aNassiri, Farshad.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031297496
776 0 8 _iPrinted edition:
_z9783031297519
776 0 8 _iPrinted edition:
_z9783031297526
830 0 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1416
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-29750-2
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